US 9,067,048 B2 · Medication liquid supporting jig and method of applying medication to micro-needle using same

Abstract

Provided are a jig for uniformly applying a drug liquid to a microneedle, and a method of applying a drug to a microneedle using same. Grooves of a number corresponding to the number of rows of small needles of a microneedle are formed in the surface of a flat plate jig or of a roller-like jig, and a drug liquid is filled and held in the grooves. The drug liquid is applied to the microneedle by inserting the small needles of the microneedle into the surface of the drug liquid held in the narrow grooves, and immersing the small needles in the drug liquid. By this, the drug liquid is uniformly applied to the small needles of the microneedle without unevenness between the central section and the peripheral section of each microneedle, and thus the microneedles having good quality can be easily manufactured.

Claims10

Dependent claims

A jig for allowing small needles of a microneedle to carry a liquid drug wherein

(1) the jig has a roll-like shape with one or more liquid drug holding grooves, wherein
(a) a pitch distance between the grooves is 300 to 1000 μm;
(b) a width of each groove is 100 to 700 μm;
and
(c) a depth of each groove is 100 to 700 μm, and
(2) the microneedle is a pin-frog-shaped plate having a size of 0.5 to 1.5 cm long and wide, on which 9 to 500 small needles are placed, wherein
(a) the small needles of the microneedles are made of an aliphatic polyester selected from the group consisting of polylactic acid, polyglycolic acid, and a copolymer of lactic acid and glycolic acid,
(b) the height of the small needles is 200 μm to 1 mm;
(c) the maximum diameter of the base of the small needles is 50 μm to 500 μm;
(d) the pitch distance between the small needles is 300 μm to 1 mm, and
(e) the small needles are aligned in 3 to 30 horizontal rows and 3 to 30 vertical rows.

8 more elements

A method of carrying a liquid drug on small needles of a microneedle, comprising

(i) providing a jig for allowing small needles of the microneedle to carry the liquid drug, wherein
(1) the jig has a roll-like shape with one or more liquid drug holding grooves, wherein
(a) a pitch distance between the grooves is 300 to 1000 μm,
(b) a width of each groove is 100 to 700 μm, and
(c) a depth of each groove is 100 to 700 μm, and
(2) the microneedle is a pin-frog-shaped plate having a size of 0.5 to 1.5 cm long and wide, on which 9 to 500 small needles are placed, wherein
(a) the small needles of the microneedle are made of an aliphatic polyester selected from the group consisting of polylactic acid, polyglycolic acid, and a copolymer of lactic acid and glycolic acid,
(b) the height of the small needles is 200 μm to 1 mm;
(c) the maximum diameter of the base of the small needles is 50 μm to 500 μm;
(d) the pitch distance between the small needles is 300 μm to 1 mm, and
(e) the small needles are aligned in 3 to 30 horizontal rows and 3 to 30 vertical rows,
(ii) immersing the lower part of the roll of the jig in a liquid drug tank,
(iii) rotating the roll of the jig,
(iv) wiping off the liquid drug that has adhered to the roll surface of the jig with a plate-like tool so that the liquid drug is carried only in the liquid drug holding grooves,
(v) setting the microneedle such that the small needles of the microneedle can be immersed in the liquid drug holding grooves in the upper part of the roll, whereby the small needles can pass through the liquid drug holding grooves in the upper part of the roll, and
(vi) passing the small needles through the liquid drug holding grooves to allow adhesion of the liquid drug only to the surface of the small needles.

13 more elements

Dependencies are inferred from the claim text.

Medication liquid supporting jig and method of applying medication to micro-needle using same

Life of this patent

Medication liquid supporting jig and method of applying medication to micro-needle using same

Life of this patent

Abstract

Claims10