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US 9,066,986 B2Granted
Anti-CEACAM6 antibodies and uses thereof
AssigneeNational Research Council of Canada
InventorsJianbing Zhang, Toya Nath Baral, Yanal Murad
Life of this patent
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Abstract
The present invention relates to isolated or purified antibodies or fragments thereof specific for CEACAM6 and their use as therapeutic or diagnostic tools. Specifically, the present invention is directed to antibodies or fragments thereof specific for a linear epitope of CEACAM6. In vivo and in vitro methods of diagnosis as well as therapeutic methods are also described.
Claims23
A recombinant antibody or fragment thereof specific for CEACAM6, wherein the antibody or fragment thereof binds to an epitope consisting of the sequence NRIGYSWYKG (SEQ ID NO:
- 7).
A single domain antibody, comprising
- a complementarity determining region (CDR) 1 comprising the sequence of GRTNSVYTMG (SEQ ID NO:1);
- a CDR2 comprising the sequence of IMWGAGTNTHYADSVKG (SEQ ID NO:2);
- and
- a CDR3 comprising the sequence of AANRGIPIAGRQYDY (SEQ ID NO:3), wherein the single domain antibody is specific for CEACAM6.
1 more element
Dependencies are inferred from the claim text.