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US 9,066,985 B2Granted
Fluorine-18 labeled rhodamine derivatives for imaging with positron emission tomography
AssigneeChildren's Medical Center Corporation
InventorsAlan B. Packard, Tobias K. Heinrich, S. Ted Treves, Vijay Gottumukkala
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Abstract
The present invention is directed toward novel fluorine-18 labeled rhodamine dye derivatives and methods of making the same. The present invention is also directed toward methods of using novel fluorine-18 labeled rhodamine dye derivatives as positron emission tomography imaging agents and myocardial perfusion imaging agents.
Claims12
A compound comprising an 18F labeled rhodamine derivative according to formula I:
- wherein R1, R3, and R5 are hydrogen;
- R2 and R4 are alkyl;
- A1 is carbon or nitrogen, if A1 is nitrogen, then R6 is absent;
- R6 is hydrogen;
- R7, R8 and R9 are hydrogen;
- R15 is —(CH2CH2O)mCH2CH218F, wherein m is 1-50;
- and
- A- is an anion.
5 more elements
Dependencies are inferred from the claim text.