US 9,066,983 B2 · Peptidic antigen that induces antibody recognizing three-dimensional structure of HIV and method for synthesizing same

Abstract

An object of the present invention is to provide an HIV antibody-inducing peptide antigen that is effective in developing an antibody or a vaccine having specificity and binding activity for the three-dimensional structure of a neutralization target, i.e. the mechanism by which HIV invades a target cell; a method for synthesizing the same; a vaccine comprising the peptide antigen, or an HIV three-dimensional structure-recognizing antibody induced by the peptide antigen; and a preventive and/or therapeutic agent for HIV infection comprising the peptide antigen, the vaccine, or the HIV three-dimensional structure-recognizing antibody as an active ingredient.

Claims8

Dependent claims

A peptide antigen capable of inducing an HIV three-dimensional structure-recognizing antibody that recognizes a trimer region of a N-terminal helical region of an HIV particle transmembrane protein gp41 (N36), wherein the peptide antigen comprises:

a trimer of N36 peptide derivatives comprising three N36 peptide derivatives ligated to a C3-symmetric template compound having three equivalent linker structures, wherein each N36 peptide derivatives comprises SEQ ID NO:
1;
and wherein the C3-symmetric template compound having three equivalent linker structures is the compound of formula (1):
(wherein X represents a positive integer).

1 more element

Dependencies are inferred from the claim text.

Facts

Application

13/319,813Filed 14 May 2010

Priority

JP 2009-12035218 May 2009

Published

US 2012/0052090 A11 Mar 2012

Granted

30 Jun 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 47/641
Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is…:…
A61K 39/12
Medicinal preparations containing antigens or antibodies: viral antigens
A61K 39/21
Viral antigens: retroviridae, e.g. equine infectious anemia virus
A61P 31/18
For RNA viruses: for HIV

Peptidic antigen that induces antibody recognizing three-dimensional structure of HIV and method for synthesizing same

Life of this patent

Peptidic antigen that induces antibody recognizing three-dimensional structure of HIV and method for synthesizing same

Life of this patent

Abstract

Claims8