Amide dendrimer compositions
AssigneeGenzyme Corporation
InventorsPradeep K. Dhal, David J. Harris, Stephen Randall Holmes-Farley, Chad C. Huval, Vitaly Nivorozhkin, Bruce Shutts
Life of this patent
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Abstract
Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.
Claims3
A method of treating hyperphosphatemia comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising,
- a) an amide compound represented by the following Formula III:
- wherein
- R3 is independently represented by the following Formula II:
- wherein
- p, q and r independently represent an integer from 0-2;
- R4 independently represents
- wherein
- m independently represents an integer from 1-20;
- R5 independently represents a hydrogen radical;
- a substituted or un-substituted alkyl radical;
- a substituted or un-substituted aryl radical;
- or R5 and a neighboring R5 together represent a link or links comprising a residue of a crosslinking agent, a substituted or un-substituted alicyclic radical, a substituted or un-substituted aromatic radical, or a substituted or un-substituted heterocyclic radical;
- or R5 represents a link with another compound;
- b) a crosslinking agent or residue thereof;
- and
- c) a pharmaceutically acceptable excipient.
A method of treating hyperphosphatemia comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising
- a) an amide compound represented by the following Formula V:
- wherein
- R3 is independently represented by the following Formula II:
- wherein
- p, q and r independently represent an integer from 0-2;
- R4 independently represents
- wherein
- m independently represents an integer from 1-20;
- R5 independently represents a hydrogen radical;
- a substituted or un-substituted alkyl radical;
- a substituted or un-substituted aryl radical;
- or R5 and a neighboring R5 together represent a link or links comprising a residue of a crosslinking agent, a substituted or un-substituted alicyclic radical, a substituted or un-substituted aromatic radical, or a substituted or un-substituted heterocyclic radical;
- or R5 represents a link with another compound;
- b) a crosslinking agent or residue thereof;
- and
- c) a pharmaceutically acceptable excipient.
A method of treating hyperphosphatemia comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising
- a) an amide compound represented by the following Formula VI:
- b) a crosslinking agent or residue thereof;
- and
- c) a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.