Back to results
US 9,066,970 B2Granted
Pharmaceutical compositions containing substituted 6-deoxy-6-sulfanylcyclodextrin
AssigneeFresenius Medical Care Deutschland GmbH
InventorsThomas Fichert, Johannes Gerber, Ingo Bichlmaier
Life of this patent
Estimating the term…
Abstract
The present invention relates to pharmaceutical compositions containing substituted 6-deoxy-6-sulfanylcyclodextrins as well as their use as osmotic agents, in particular for use in dialysis therapy.
Claims5
A dialysis solution comprising
- (i) at least one 6-deoxy-6-sulfanylcyclodextrin of the general structure I:
- where
- a) X stands for S—R or —OH, wherein S—R is present at a degree of substitution≧0.0001 and ≦n
- b) n stands for 6, 7 or 8,
- c) R is selected from the group consisting of C1-6-alkyl-NR1R2, C1-6-alkyl-N+R3R4R5, C1-6-alkyl-COOH, C(═O)C1-6-alkyl-COOH, —C(═O)—CH2—C(OH)(COOH)—CH2—COOH, dihydroxylated C1-6-alkyl, C1-6-alkyl-PO3H2 and —C1-6-alkyl-SO3H,
- where R1, R2, R3, R4 and R5, independently of one another, stand for H or —C1-3-alkyl, and
- (ii) the following ingredients in the following concentrations:
- Ca2⊕ 0.5 to 5 meq/L;
- Mg2⊕ 0 to 3.0 meq/L;
- Cl⊖ 90.5 to 121 meq/L;
- K⊕ 0 to 4.0 meq/L;
- HCO3⊖ 25 to 40 meq/L.
9 more elements
Dependencies are inferred from the claim text.