Dry powder inhaler
AssigneeTeva Branded Pharmaceutical Products R&D, Inc.
InventorsMukul Dalvi, Seah Kee Tee
Life of this patent
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Abstract
This invention provides a dry powder inhaler comprising: a dry powder medicament comprising fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein, the delivered dose of salmeterol per actuation is less than 50 μg; and wherein the dose provides a baseline-adjusted FEV1 in a patient of more than 150 mL within 30 minutes of receiving the dose. A method of treating a patient includes administering to a patient a dry powder medicament having fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein, the delivered dose of salmeterol per actuation is less than 50 μg; and wherein the dose provides a baseline-adjusted FEV1 in a patient of more than 150 mL within 30 minutes of receiving the dose.
Claims20
A dry powder inhaler comprising:
- a dry powder medicament comprising fluticasone propionate, salmeterol xinafoate and a lactose carrier;
- wherein, the delivered dose of salmeterol per actuation is less than 50 μg;
- and
- wherein the dose provides a baseline-adjusted FEV1 in a patient of more than 150 mL within 30 minutes of receiving the dose.
A method for the treatment of asthma or allergic rhinitis or COPD comprising administering to a patient a dry powder medicament comprising fluticasone propionate, salmeterol xinafoate and a lactose carrier;
- wherein, the delivered dose of salmeterol per actuation is less than 50 μg;
- and wherein the dose provides a baseline-adjusted FEV1 in a patient of more than 150 mL within 30 minutes of receiving the dose.
A method of measuring a delivered dose of active agent by an inhaler comprising:
- inserting the inhaler into a mouthpiece adapter;
- actuating the inhaler to provide a delivered dose through the mouthpiece adapter and into a dosage unit sampling apparatus;
- rinsing the mouthpiece adapter with a solvent and into the dosage unit sampling apparatus;
- dissolving the delivered dose in the dosage unit sampling apparatus;
- filtering the dissolved delivered dose to provide a filtered solution;
- and analyzing the filtered solution to determine the amount of the active agent in the delivered dose.
Dependencies are inferred from the claim text.