Fused heterocyclic derivatives and methods of use

A compound of formula II

• or a pharmaceutically acceptable salt thereof wherein
• J is N;
• W is CR2b;
• Z and Z* are independently —O— or —NR5—;
• Ra, Rb, Rc and Rd are each independently H, halo, alkyl, any of which may be optionally independently substituted with one or more R10 groups as allowed by valence;
• R1 is aryl, heteroaryl or heterocyclo any of which may be optionally independently substituted with one or more R10 groups as allowed by valence;
• R2 is
• (i) halo, cyano, nitro, or
• (ii) alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkyl, —OR4, any of which may be optionally independently substituted with one or more R10 as allowed by valence,
• R2a, R2b and R3 are independently selected at each occurrence from H, halo, cyano, nitro, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl,
• heterocycloalkyl, —OR4, —S(O)vR4, —NR5R5a, —C(═O)R4, —C(═S)R4, —C(═O)OR4, —C(═S)OR4, —C(═O)NR5R5a, —C(═S)NR5R5a, —N(R5)C(═O)NR5R5a, —N(R5)C(═S)NR5R5a, —N(R5)C(═O)R4, —N(R5)C(═S)R4, —OC(═O)NR5R5a, —OC(═S)NR5R5a, —SO2NR5R5a, —N(R5)SO2R4, —N(R5)SO2NR5R5a, —N(R5)C(═O)OR4, —N(R5)C(═S)OR4, —N(R5)SO2R4, any of which may be optionally independently substituted with one or more R10 groups as allowed by valence;
• R4 is independently selected at each occurrence from H, alkyl, haloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl, heterocycloalkyl, and cycloalkylalkyl, any of which may be optionally independently substituted as allowed by valence with one or more R10 groups;
• R5 and R5a are independently selected at each occurrence from H, alkyl, haloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclo, arylalkyl, heteroarylalkyl, heterocycloalkyl, and cycloalkylalkyl, any of which may be optionally substituted as allowed by valence with one or more R10;
• R10 at each occurrence is independently, halo, nitro, oxo, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl,
• heterocycloalkyl, -(alkylene)m-OR4, -(alkylene)m-S(O)vR4, -(alkylene)m-NR5R5a, -(alkylene)m-C(═O)R4, -(alkylene)m-C(═S)R4, -(alkylene)m-C(═O)OR4, -(alkylene)m-OC(═O) R4, -(alkylene)m-C(═S)OR4, -(alkylene)m-C(═O)NR5R5a, -(alkylene)m-C(═S)NR5R5a, -(alkylene)m-N(R5)C(═O)NR5R5a, -(alkylene)m-N(R5)C(═S)NR5R5a, -(alkylene)m-N(R5)C(═O)R4, -(alkylene)m-N(R5)C(═S)R4, -(alkylene)m-OC(═O)NR5R5a, -(alkylene)m-OC(═S)NR5R5a, -(alkylene)m-SO2NR5R5a, -(alkylene)m-N(R5)SO2R4, -(alkylene)m-N(R5)SO2NR5R5a, -(alkylene)m-N(R5)C(═O)OR4, -(alkylene)m-N(R5)C(═S)OR4,
• or -(alkylene)m-N(R5)SO2R4;
• wherein said alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclo, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, and heterocycloalkyl groups may be further independently substituted with one or more -(alkylene)m-OR4, -(alkylene)m-S(O)vR4, -(alkylene)m-NR5R5a, -(alkylene)m-C(═O)R4, -(alkylene)m-C(═S)R4, -(alkylene)m-C(═O)OR4, -(alkylene)m-OC(═O)R4, -(alkylene)m-C(═S)OR4,
• -(alkylene)m-C(═O)NR5R5a, -(alkylene)m-C(═S)NR5O, -(alkylene)m-N(R5)C(═O)NR5R5a, -(alkylene)m-N(R5)C(═S)NR5R5a, -(alkylene)m-N(R5)C(═O)R4, -(alkylene)m-N(R5) C(═S)R4, -(alkylene)m-OC(═O)NR5R5a, -(alkylene)m-OC(═S)NR5R5a, -(alkylene)m-SO2NR5R5a, -(alkylene)m-N(R5)SO2R4, -(alkylene)m-N(R5)SO2NR5R5a, -(alkylene)m-N(R5)C (═O)OR4, -(alkylene)m-N(R5)C(═S)OR4, or -(alkylene)m-N(R5)SO2R4;
• m is 0 or 1;
• n is 0, 1 or 2;
• q and t are each independently 0 or 1;
• v is 0, 1 or 2.