Production of moldable bone substitute
AssigneePromimic AB
InventorsPer Kjellin, Paul Handa
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Abstract
Composites and methods of producing a moldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.
Claims36
A method of producing a scaffold for bone growth comprising:
- mixing together a first solution comprising a calcium compound and a second solution comprising a phosphoric acid compound;
- forming a suspension comprising calcium phosphate particles having a length of 10-20 nm;
- and
- combining the calcium phosphate particles with a biodegradable polymer and one or more plasticizers to form a composite;
- heating the composite to a temperature sufficient to form a shapeable composite;
- and
- cooling the shapeable composite to room temperature,
- wherein the shapeable composite is shaped by hand for a given period of time after the heating step, thereby forming the scaffold for bane growth.
A method of producing a nanocrystalline hydroxyapatite (HA) scaffold for bone growth comprising:
- mixing together a first solution comprising a calcium compound and a second solution comprising a phosphoric acid compound;
- forming a suspension comprising nanocrystalline HA particles having a length of 10-20 nm and a specific surface area of 200 m2/g or greater;
- and
- combining the nanocrystalline HA particles with a biodegradable polymer and one or more plasticizers to form a nanocrystalline HA composite, thereby forming the nanocrystalline HA scaffold for bone growth.
A method of producing a scaffold for bone growth comprising:
- mixing together a first solution comprising a calcium compound and a second solution comprising a phosphoric acid compound;
- forming a suspension comprising calcium phosphate particles having a length of 10-20 nm;
- and
- combining the calcium phosphate particles with a biodegradable polymer and one or more plasticizers to form a composite, the composite comprising 1,2,3-triacetoxypropane and poly-caprolactone;
- heating the composite to a temperature sufficient to form a shapeable composite;
- and
- cooling the shapeable composite to room temperature, thereby forming the scaffold for bone growth.
A method of producing a nanocrystalline hydroxyapatite (HA) scaffold for bone growth comprising:
- mixing together a first solution comprising a calcium compound and a second solution comprising a phosphoric acid compound;
- forming a suspension comprising nanocrystalline HA particles having a length of 10-20 nm;
- and
- combining the nanocrystalline HA particles with a biodegradable polymer and one or more plasticizers to form a nanocrystalline HA composite comprising 1,2,3-triacetoxypropane and poly-caprolactone, thereby forming the nanocrystalline HA scaffold for bone growth.
Dependencies are inferred from the claim text.