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US 9,066,925 B2Granted
Methods of stimulating liver regeneration
AssigneeMUSC Foundation for Research Development
InventorsStephen Tomlinson, Songqing He, Carl Atkinson
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Abstract
Provided herein are methods and compositions, including pharmaceutical compositions, for stimulating liver regeneration after partial hepatectomy, massive liver resection and toxic injury, or following liver transplantation, including small-for-size liver transplantation, by inhibiting activation of complement.
Claims19
A method of stimulating liver regeneration after partial hepatectomy in an individual in need thereof, the method comprising administering to the individual a complement inhibitor that inhibits complement activation at the C3 level,
- wherein the complement inhibitor is administered in a dose therapeutically effective to increase IL-6 levels in the priming phase in regeneration but not sufficient to substantially deplete cell surface C3d deposition in the individual;
- and
- wherein the complement inhibitor is a complement receptor 2 (CR2)-factor H (FH) molecule comprising:
- i) a CR2 portion comprising at least the first two N-terminal short consensus repeat (SCR) domains of human CR2, and
- ii) a FH portion comprising at least the first four N-terminal SCR domains of human FH.
2 more elements
Dependencies are inferred from the claim text.