Hyaluronan as a chemo-sensitizer in the treatment of cancer
AssigneeAlchemia Oncology Pty Limited
InventorTracey J. Brown
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Abstract
This application provides methods and compositions for the treatment of cancer. The application provides compositions including hyaluronic acid and a chemotherapeutic agent such as irinotecan that are useful in the treatment of cancer.
Claims23
A method of treating a solid tumor cancer comprising the step of intravenously administering to a subject, with said solid tumor cancer in need thereof, a therapeutically effective amount of a composition comprising a cancer chemotherapeutic and a hyaluronan, wherein the hyaluronan has a size expressed as a molecular weight of 800,000 to 1,432,000 Daltons or an intrinsic viscosity of 10.0 dl/gm to 14.5 dl/gm, and wherein the cancer is selected from the group consisting of cancers of the lung, pancreas, and colorectal.
A method of treating a patient with a solid tumor cancer comprising the administration intravenously of a composition comprising a therapeutically effective amount of irinotecan (CPT 11) together with hyaluronan, wherein the hyaluronan has a size expressed as a molecular weight of 800,000 to 1,432,000 Daltons or an intrinsic viscosity of 10.0 dl/gm to 14.5 dl/gm, to a patient with said solid tumor cancer in need of such treatment, and wherein the cancer is selected from the group consisting of cancers of the lung, pancreas, and colorectal.
Dependencies are inferred from the claim text.