Methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol

A method to improve the efficacy and/or reduce the side effects of suboptimally administered drug therapy comprising the steps of:

• (a) identifying at least one factor or parameter associated with the efficacy and/or occurrence of side effects of the drug therapy;
• and
• (b) modifying the factor or parameter to improve the efficacy and/or reduce the side effects of the drug therapy;
• wherein the suboptimally administered drug therapy comprises administration of a substituted hexitol and wherein the substituted hexitol is selected from the group consisting of dianhydrogalactitol and diacetyldianhydrogalactitol;
• and
• wherein the factor or parameter is selected from the group consisting of:
• (a) route of administration;
• (b) schedule of administration;
• (c) indications for use;
• (d) selection of disease stage;
• (e) other indications;
• (f) patient selection;
• (g) patient/disease phenotype;
• (h) patient/disease genotype;
• (i) pre/post-treatment preparation;
• (j) toxicity management;
• (k) drug combinations;
• (l) post-treatment patient management;
• (m) drug delivery systems;
• (n) drug conjugate forms;
• (o) prodrugs;
• (p) multiple drug systems;
• (q) novel mechanisms of action;
• and
• (r) selective target cell population therapeutics.