Drug-enhanced adhesion prevention
AssigneeEthicon, Inc.
InventorsJanel E. Young, Scott A. Wadsworth, Kevin Cooper, Joel Rosenblatt, Han Cui
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Abstract
The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Tranilast, or an analog thereof, directly to tissue surfaces in the body cavity in amounts and under conditions effective to inhibit formation of adhesions, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.
Claims13
A method for the inhibition of post-operative adhesion formation in a body between tissue surfaces which have been subjected to a surgical procedure comprising locally administering a composition comprising a delivery vehicle containing Tranilast, or an analog thereof, directly onto said tissue surfaces at the surgical site in amounts and for periods of time effective to reduce the area percentage of adhesions formed thereon, relative to systemic administration of Tranilast alone.
Dependencies are inferred from the claim text.