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US 9,066,908 B2Granted
Method of treating bone disorders using TSG-6
AssigneeThe University of Manchester
InventorsAfsie Sabokbar, Anthony Day, Caroline Milner
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Abstract
The invention provides use of a TSG-6 polypeptide, or a polynucleotide encoding an TSG-6 polypeptide, in the manufacture of a medicament for the treatment or prevention of a bone disease or condition associated with bone resorption by osteoclasts.
Claims5
A method of treating osteoporosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a TSG-6 polypeptide, wherein the TSG-6 polypeptide is not administered in combination with PTX3;
- wherein the TSG-6 polypeptide comprises:
- (i) the amino acid sequence of SEQ ID NO:
- 2, 3, 5, 6, 7, 9, 10, 11 or 13, or
- (ii) an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO:
- 2, 3, 5, 6, 7, 9, 10, 11 or 13.
2 more elements
Dependencies are inferred from the claim text.