US 9,066,898 B2 · Prostate-associated antigens and vaccine-based immunotherapy regimens

Abstract

The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.

Claims13

Dependent claims

A multi-antigen construct that comprises:

(a) at least one nucleotide sequence encoding an immunogenic PSA polypeptide;
(b) at least one nucleotide sequence encoding an immunogenic PSCA polypeptide;
and
(c) at least one nucleotide sequence encoding an immunogenic PSMA polypeptide, wherein the immunogenic PSA polypeptide comprises amino acids 4-240 of SEQ ID NO:17, wherein the immunogenic PSCA polypeptide comprises the amino acid sequence of SEQ ID NO:21, and wherein the immunogenic PSMA polypeptide has at least 90% identity with amino acids 15-750 of the human PSMA of SEQ ID NO:1 and comprises the amino acids of at least 10 conserved T cell epitopes of the human PSMA at corresponding positions.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

13/875,162Filed 1 May 2013 · us provisional application

Priority

4 May 2012

Published

US 2013/0295110 A17 Nov 2013

Granted

30 Jun 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification32 codes

A61K 39/39
Medicinal preparations containing antigens or antibodies: characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 31/404
Condensed with carbocyclic rings, e.g. carbazole: indoles, e.g. pindolol
A61K 31/7088
Carbohydrates; Sugars; Derivatives thereof: compounds having three or more nucleosides or nucleotides

Prostate-associated antigens and vaccine-based immunotherapy regimens

Life of this patent

Prostate-associated antigens and vaccine-based immunotherapy regimens

Life of this patent

Abstract

Claims13