US 9,066,895 B2 · Method of storing a vaccine containing an aluminum adjuvant

Abstract

The invention relates to a method for loading and storing a vaccine composition, containing the antigen adsorbed on the aluminum adjuvant which (a) comprises (i) loading the composition into a container; and (ii) closing the container with a device in particular acting as a stopper, the surface of the device getting into contact with the composition being coated with a fluoropolymer such as Teflon™; and/or (b) loading the composition into a container wherein the inner surface of which is coated with polymerized silicone. The use of fluoropolymer or polymerized silicone optimizes the adsorbed antigen stability upon storage. In a particular embodiment, the antigen is the hepatitis B surface antigen and the aluminum adjuvant is aluminum oxy hydroxide.

Claims13

Dependent claims

A vaccine comprising a container containing a liquid multivalent vaccine composition comprising hepatitis B surface antigen adsorbed on aluminum oxyhydroxide, wherein the container

(i) has inner surfaces coated with polymerized silicone;
and
(ii) is closed by a device acting as a stopper, wherein the surface of the device contactable with the vaccine composition is coated with a fluoropolymer,
wherein the vaccine composition has reduced desorption rate of hepatitis B as compared to an otherwise identical vaccine composition stored in a standard container not having inner surfaces being coated with polymerized silicone and/or closed by a device coated with the said fluoropolymer.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

13/274,714Filed 17 Oct 2011 · us provisional application

Priority

FR 10 5846418 Oct 2010

Published

US 2012/0091026 A119 Apr 2012

Granted

30 Jun 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification22 codes

B65D 51/005
Closures not otherwise provided for: closures provided with linings or internal coatings so as to avoid contact of the closure with the contents
A61K 39/00
Medicinal preparations containing antigens or antibodies
A61K 39/05
Bacterial antigens: actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
A61K 39/08
Bacterial antigens: clostridium, e.g. Clostridium tetani

Method of storing a vaccine containing an aluminum adjuvant

Life of this patent

Method of storing a vaccine containing an aluminum adjuvant

Life of this patent

Abstract

Claims13