Yeast-based vaccines
AssigneeGlobelImmune, Inc.
InventorsAlex Franzusoff, Deborah Quick
Life of this patent
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Abstract
The invention provides methods for culturing yeast at a neutral pH level. Yeast cultured under neutral pH conditions exhibit desirable characteristics useful for biological purposes, such as the development of vaccines, prophylactics and therapeutics. The invention also provides for compositions and kits comprising yeast grown using the methodologies disclosed herein.
Claims22
A pharmaceutical composition comprising yeast from Saccharomyces that express a heterologous antigen, wherein the yeast have been cultured in a medium that has been maintained at a pH of between 5.5 and 8 for the entire time the yeast are in culture, wherein the pharmaceutical composition has been formulated for administration to an individual.
A pharmaceutical composition comprising yeast from Saccharomyces cerevisiae that express a heterologous antigen, wherein the yeast have been cultured in a buffered medium, wherein the pH of the medium did not drop below pH 5.5 while the yeast were in culture, and wherein the pharmaceutical composition is formulated for administration to an individual.
A pharmaceutical composition comprising yeast from Saccharomyces cerevisiae that express a heterologous antigen, wherein the yeast have been grown and maintained in a buffered medium at a pH of between 5.5 and 8, wherein the pH of the medium did not drop below pH 5.5 from the start of yeast growth to harvest of the yeast, and wherein the pharmaceutical composition is formulated for administration to an individual.
Dependencies are inferred from the claim text.