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US 9,066,887 B2Granted
Transdermal therapeutic system having urea components
AssigneeLTS Lohmann Therapie-Systeme AG
InventorsMichael Horstmann, Gerd Hoffmann, Sandra Wiedersberg
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Abstract
The invention relates to a transdermal therapeutic system (TTS) for administering pharmaceutical agents through the skin, comprising a back layer (R) impermeable to the agent and at least one layer (S) comprising the agent, wherein the layer (H) facing the skin comprises urea in solid form, allowing continuous administration of large quantities of agent over a long period of time.
Claims15
A transdermal therapeutic system (ITS) for delivering active pharmaceutical ingredients through the skin, comprising:
- an ingredient-impermeable backing layer (R);
- at least one ingredient-containing layer (S) comprising at least one active pharmaceutical ingredient;
- and
- a skin-facing layer (H) comprising solid urea in the form of coarse solid particles;
- wherein the weight fraction of the solid urea, as a proportion of the base material of the skin-facing layer (H) of the TTS, is at least 20% (m/m);
- wherein, among all the solid urea in the skin-facing layer (H), at least 50% by weight of the solid urea have a particle size of more than 50 μm;
- and
- wherein the ingredient-containing layer (S) is the same or is different from the skin-facing layer (H).
5 more elements
Dependencies are inferred from the claim text.