Pharmaceutical compositions for the treatment of inner ear disorders
AssigneeAuris Medical AG
InventorThomas Meyer
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Abstract
The present invention provides compositions containing (i) a pharmaceutically active agent selected from a group consisting of an arylcycloalkyamine or a derivative, analogue or pharmaceutically active salt thereof, and (ii) a biocompatible polymer or a combination of biocompatible polymers. The compositions or medicaments containing these compositions may be used for the prevention and/or treatment of inner ear diseases, e.g. tinnitus.
Claims9
A method of treating a middle or inner ear disease comprising intratympanically administering to a patient in need thereof a controlled release composition comprising a pharmaceutically active agent and a thermosetting polymer;
- wherein the pharmaceutically active agent is selected from antibiotics and is suspended in the composition, and the thermosetting polymer has a gelation temperature of at least about 15° C.,
- wherein the thermosetting polymer is poloxamer 407 and is present at a concentration of about 20% (w/w), and
- wherein the antibiotic is fluoroquinolone.
Dependencies are inferred from the claim text.