US 9,066,861 B2 · Dermaceutical cream made using sodium fusidate and steroids

Abstract

The invention discloses a dermaceutical cream containing steroids and an antibacterial agent in the form of Fusidic acid, which Fusidic acid is formed in situ from Sodium Fusidate as the starting raw material, wherein Sodium Fusidate is converted into Fusidic acid under oxygen-free environment. The cream of the present invention has greater shelf-life stability and the finer particle size of the API than the conventional creams containing Fusidic acid. The cream of the present invention contains Fusidic acid as the API that has been formed in situ from Sodium Fusidate, and steroids in a cream base comprising an acid, a co-solvent, an emulsifier and a waxy material along with water, preferably purified water.

Claims16

Dependent claims

A dermaceutical cream comprising:

(a) fusidic acid which is made in situ under an oxygen-free environment using sodium fusidate, wherein the cream comprises fusidic acid made by dissolving sodium fusidate in a co-solvent under inert gas purging and under vacuum, and converting the sodium fusidate to fusidic acid in situ by adding an acid under stirring;
(b) at least one corticosteroid;
and
(c) a cream base comprising at least one preservative, at least one of each of primary and secondary emulsifier, a waxy material, and water.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

13/144,932Filed 20 Jan 2010

Priority

IN 134/MUM/200921 Jan 2009

Published

US 2011/0281830 A117 Nov 2011

Granted

30 Jun 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 9/06
Medicinal preparations characterised by special physical form: ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 31/56
Medicinal preparations containing organic active ingredients: compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives…
A61P 17/00
Drugs for dermatological disorders

Dermaceutical cream made using sodium fusidate and steroids

Life of this patent

Dermaceutical cream made using sodium fusidate and steroids

Life of this patent

Abstract

Claims16