Implantable therapeutic device

An ophthalmic drug delivery system comprising:

• an extended release device configured to be implanted in an eye, the device comprising:
• a reservoir having a reservoir volume;
• and
• a rigid porous structure coupled to the reservoir having a plurality of interconnecting, irregularly shaped channels, the porous structure located at a distal region of the reservoir, the rigid porous structure having a release rate tuned to release a predetermined rate profile of a drug formulation from the reservoir and into the eye to treat the eye for an extended period of time;
• and
• a drug formulation contained in and delivered by the extended release device, wherein the drug formulation comprises an inhibitor of complement factor D having a concentration in a solution volume and a given half-life upon bolus injection of the solution volume into the eye,
• wherein the extended release device is tuned to the drug formulation by selecting a value for at least one of the group consisting of:
• the concentration, the reservoir volume, and the release rate, to achieve an effective half-life in the eye when the drug formulation is delivered by the implantable extended release device,
• wherein the effective half-life is longer than the given half-life;
• and
• wherein the rigid porous structure has a porosity P between about 3% to about 70% corresponding to the percentage of void spaces extending within the rigid porous structure.