Neuromodulation cryotherapeutic devices and associated systems and methods

A cryotherapeutic device, comprising:

• an elongated shaft having a distal portion configured to be located intravascularly at a treatment site in a renal artery or ostium;
• a supply lumen extending along a length of the shaft, the supply lumen being configured to receive liquid refrigerant;
• a cooling assembly at the distal portion of the shaft, the cooling assembly having a delivery state and a developed state, the cooling assembly including
• an orifice in fluid coomunication with the supply lumen, and
• an applicator configured to cause therapeutically-effective cryogenic renal-nerve modulation when the cooling assembly is in the deployed state and when the cooling assembly receives refrigerant from the supply lumen, the applicator having a heat-transfer portion in fluid communication with the orifice,
• wherein
• the balloon is elongated and has a proximal portion, a distal portion, and a middle portion therebetween,
• the balloon has a first wall portion with a concave curvature along a length of the balloon and a second wall portion having a non-concave curvature along the length of the balloon when the cooling assembly is in the deployed state,
• the middle portion of the balloon is configured to contact the renal artery or ostium along the second wall potion and not the first wall portion when the cooling assembly is in the deployed state,
• the second wall portion of the balloon at the middle portion of the balloon at least partially defines the heat-transfer portion of the applicator, and
• the heat-transfer portion of the applicator is non-circumferential at longitudinal segments disposed along a length of the applicator;
• and
• an occlusion member spaced apart proximally from the applicator, the occlusion member having a collapsed state, an expanded state, and a cross-sectional dimension that fully occludes the renal artery or ostium proximal of the treatment site when the occlusion member is in the expanded state.

A cryotherapeutic device, comprising:

• an elongated shaft having a distal portion configured to be located intravascularly at a treatment site in a renal artery or ostium;
• a supply lumen extending along a length of the shaft, the supply lumen being configured to receive liquid refrigerant;
• a cooling assembly at the distal portion of the shaft, the cooling assembly having a delivery state and a deployed state, the cooling including
• an elongated shaping member extending along a length of the cooling assembly,
• a shaping member having a linear configuration when the cooling assembly is in the delivery state and a curvilinear configuration when the cooling assembly is in the deployed state,
• an orifice in fluid communication with the supply lumen, and
• an applicator configured to cause therapeutically-effective cryogenic renal-nerve modulation when the cooling assembly is in the deployed state and when the cooling assembly receives refrigerant from the supply lumen, the applicator having a balloon that defines a chamber, the balloon having a heat-transfer portion in fluid communication with the orifice, the balloon having a shape when the cooling assembly is in the deployed state that at least partially corresponds to the curvilinear configuration of the shaping member;
• and
• an occlusion member spaced apart proximally from the applicator, the occlusion member having a collapsed state, an expanded state, and a cross-sectional dimension that fully occludes the renal artery or ostium proximal to the treatment site when the occlusion member is in the expanded state.

A cryotherapeutic device, comprising:

• an elongated shaft having a distal portion configured to be located intravsacularly at a treatment site in a renal artery or ostium;
• a supply lumen extending along a length of the shaft, the supply lumen being configured to receive liquid refrigerant;
• an elongated shaping member longitudinally movable relative to the shaft;
• a cooling assembly at the distal portion of the shaft, the cooling assembly having
• a delivery state and a deployed state, the cooling assembly including
• an orifice in fluid communication with the supply lumen, and
• an applicator configured to cause therapeutically-effective cryogenic renal-nerve modulation when the cooling assembly is in the deployed state and when the cooling assembly receives refrigerant from the supply lumen, the applicator having
• a first elongated balloon with a heat-transfer portion in fluid communication with the orifice, the first balloon having a proximal portion, a distal portion, and a middle portion therebetween,
• a second elongated balloon having a proximal portion, a distal portion, and middle portion, therebetween,
• wherein
• the distal portion of the first and second balloons are attached to the shaping member such that retracting the shaping member relative to the shaft causes the first and second balloons to curve along a length of the cooling assembly, and the middle portions of the first and second balloons to laterally move away from the shaping member,
• the middle portion of the first balloon has an outer side with a non-concave curvature along the length of the cooling assembly when the cooling assembly is in the deployed state,
• the middle portion of the second balloon has an outer side with a non-concave curvature along the length of the cooling assembly when the cooling assembly is in the deployed state,
• the outer sides of the middle portions of the first and second balloons at least partially define the heat-transfer portion, and
• the heat-transfer portion is non-circumferential at longitudinal segments along the length of the cooling assembly;
• and
• an occlusion member spaced apart proximally from the applicator, the occlusion member having a collapsed state, an expanded state, and a cross-sectional dimension that fully occludes the renal artery or ostium proximal to the treatment site when the occlusion member is in the expanded state.