Applicators for storing sterilizing, and dispensing an adhesive

An applicator for storing and dispensing an adhesive comprising:

• a) a flexible handle comprising a distal end, a housing for containing a removable adhesive container, and a female end of a luer lock at the distal end of the handle;
• b) a body comprising a proximal end and a distal end, a male end of a luer lock at the proximal end of the body, said male end being capable of connecting to the female end at the distal end of the handle, and a channel extending through the body, and having an opening at the distal end of the body;
• c) a porous tip in communication with the channel opening at the distal end of the body;
• and
• d) a removable container comprising a distal end, and comprising a single layer of a copolymer of acrylonitrile and methyl acrylate or comprising multiple layers with the inner-most layer comprising a copolymer of acrylonitrile and methyl acrylate, said container being capable of fitting within the housing, and further comprising a frangible seal covering the distal end of the container and having a side in communication with an adhesive stored in the container, said adhesive comprising a cyanoacrylate monomer, a free radical stabilizer in an amount of 200 ppm to 15,000 ppm, and an anionic stabilizer in an amount of about 10 ppm to about 200 ppm;
• wherein the applicator is activated by compromising the frangible seal whereupon the adhesive may flow into and through the channel and out of the porous tip, and wherein at least the container is sterilized by radiation, and the adhesive stored in the container does not cure upon radiation exposure and for at least about twelve months of shelf storage thereafter.

An applicator for storing and dispensing an adhesive comprising:

• a) a container comprising walls defining a chamber having a distal end and an opening at the distal end of the chamber, said walls comprising a single layer of a copolymer of acrylonitrile and methyl acrylate or comprising multiple layers with the inner-most layer comprising a copolymer of acrylonitrile and methyl acrylate, a frangible seal covering the opening and having a side in communication with the chamber, an adhesive comprising a cyanoacrylate monomer, a free radical stabilizer in an amount of 200 ppm to 15,000 ppm, and an anionic stabilizer in an amount of about 10 ppm to about 200 ppm stored in the chamber, and optionally, screw threads on the exterior of the walls of the container;
• b) a body comprising a proximal end and a distal end, a cavity at the proximal end of the body, a channel having a proximal end and a distal and, said channel being in communication with the cavity, extending through the body, and having an opening at the distal end of the channel, a grip capable of constricting the channel when inward pressure is applied to the grip, at least one projection in the cavity, wherein the projection is capable of penetrating the frangible seal when the body and the container are compressed together, and optionally, screw threads on the walls of the cavity capable of engaging the screw threads on the exterior of the walls of the container;
• and
• c) a porous tip in communication with the opening at the distal end of the channel;
• wherein the applicator is activated by compressing the body and the container together whereupon the projection penetrates the frangible seal and allows the adhesive to flow into and through the channel and out of the porous tip, and wherein at least the container is sterilized by radiation, and the adhesive stored in the chamber of the container does not cure upon radiation exposure and for at least about twelve months of shelf storage thereafter.