Methods to generate luminal organ profiles using impedance

A method of creating a cross-sectional area profile of a targeted treatment site, the method comprising the steps of:

• introducing an impedance device having at least two electrodes positioned thereon into a luminal organ;
• measuring a first treatment site conductance at the first position using the impedance device and a first injection of a solution having a known conductivity, the first injection being made within the luminal organ so that an undiluted bolus of the first injection flows from a first injection location through the luminal organ to the first position prior to ultimate dilution within the luminal organ, the first treatment site conductance measured prior to ultimate dilution of the injection within the luminal organ at the first position;
• moving the impedance device to a second position in the luminal organ;
• measuring a second treatment site conductance at the second position using the impedance device and a second injection of a solution having a known conductivity, the second injection being made within the luminal organ so that an undiluted bolus of the second injection flows from a second injection location through the luminal organ to the second position prior to ultimate dilution within the luminal organ, the second treatment site conductance measured prior to ultimate dilution of the injection within the luminal organ at the second position;
• calculating a first position cross-sectional area based in part upon the first treatment site conductance, a conductivity of blood, and a known distance between two of the at least two detection electrodes and calculating a second position cross-sectional area using the second treatment site conductance, the conductivity of blood, and the known distance between two of the at least two detection electrodes;
• and
• constructing a profile of the treatment site based in part on the calculated first cross-sectional area and the calculated second cross-sectional area.

A method of creating a cross-sectional area profile of a targeted treatment site, the method consisting essentially of the steps of:

• introducing an impedance device having at least two detection electrodes positioned in between at least two excitation electrodes into a treatment site of a luminal organ at a first position;
• measuring a first treatment site conductance at the first position using the impedance device and at least two injections of solutions having different conductivities, the at least two injections being made within the luminal organ so that undiluted boluses of the at least two injections flow from an injection location through the luminal organ to the first position prior to ultimate dilution within the luminal organ, the first treatment site conductance measured prior to ultimate dilution of the injections within the luminal organ at the first position;
• moving the impedance device to a second position in the luminal organ;
• measuring a second treatment site conductance at the second position using the impedance device and the at least two injections of solutions having different conductivities, the at least two injections being made within the luminal organ so that undiluted boluses of the at least two injections flow from an injection location through the luminal organ to the second position prior to ultimate dilution within the luminal organ, the second treatment site conductance measured prior to ultimate dilution of the injections within the luminal organ at the second position;
• moving the impedance device to at least one additional position in the luminal organ;
• measuring at least one additional treatment site conductance at the at least one additional position using the impedance device and the at least two injections of solutions having different conductivities;
• calculating a first position cross-sectional area based in part upon the first treatment site conductance, a second position cross-sectional area based in part upon the second treatment site conductance, and at least one additional position cross-sectional area based in part upon the at least one additional treatment site conductance, with each calculation also being based in part upon a conductivity of blood and a known distance between two of the at least two detection electrodes;
• constructing a profile of the treatment site based in part on the calculated first cross-sectional area, the calculated second cross-sectional area, and the calculated at least one additional cross-sectional area.