Multiple sclerosis therapeutic methods using therapeutic delivery devices and systems

A multiple sclerosis therapeutic method, comprising:

• providing a treatment device that includes:
• a catheter having a proximal portion, a distal portion, a central lumen extending along a length of the catheter between the proximal and distal portions, and an off-set lumen extending along the length of the catheter between the proximal and distal portions;
• a balloon coupled to the distal portion of the catheter such that the balloon is in fluid communication with the off-set lumen of the catheter such that a therapeutic agent can be introduced into the balloon through the off-set lumen, wherein the therapeutic agent is configured to dissolve fibrin or thrombus present at a lesion of a vein and wherein the balloon is configured to facilitate application of the therapeutic agent from the balloon to the lesion when the balloon is positioned adjacent the lesion;
• and
• an intravascular ultrasound (IVUS) component adjacent to the balloon, wherein the IVUS component is configured to image the vein;
• identifying at least one venous outflow obstruction site of a patient based on images obtained from the IVUS component;
• assessing the at least one venous outflow obstruction site to determine whether the at least one venous outflow obstruction site causes significant narrowing of the vein, wherein venous outflow obstruction sites causing significant narrowing of the vein are identified for treatment with the therapeutic agent via the balloon;
• verifying the at least one venous outflow obstruction site by determining a pressure gradient across the at least one venous outflow obstruction site;
• and
• applying the treatment device to an identified venous outflow obstruction site of the vein to treat multiple sclerosis symptoms of the patient, including inflating the balloon adjacent to the identified venous outflow obstruction site to apply the therapeutic agent to the identified venous outflow obstruction site to increase a cross-sectional area of a lumen of the vein.