Radiopaque shape memory polymers for medical devices
AssigneeEndoshape, Inc.
InventorsStephen Dean Goodrich, Michael Lyons, Jeffrey Paul Castleberry
Life of this patent
Estimating the term…
Abstract
Radiopaque polymer compositions and methods for making the compositions are provided. These radiopaque polymer compositions include shape memory polymer compositions comprising a crosslinked polymer network, the network comprising a first repeating unit derived from a monofunctional iodinated monomer and a second repeating unit derived from a multifunctional non-iodinated monomer wherein neither of the two monomers is fluorinated. Devices formed from radiopaque polymer compositions are also provided.
Claims33
A polymer composition comprising a crosslinked network, the network comprising:
- a) a first repeating unit having the formula:
- wherein R1 is substituted or unsubstituted C2-C36 alkylene, C2-C36 cycloalkylene, C2-C36 alkenylene, C2-C36 cycloalkenylene, C2-C36 alkynylene, C5-C36 arylene, or C5-C36 heteroarylene;
- L1 is a —(CH2)n—, —(HCCH)n—, —O—, —S—, —SO—, —SO2—, —SO3—, —OSO2—, —NR2—, —CO—, —COO—, —OCO—, —OCOO—, —CONR3—, —NR4CO—, —OCONR5—, —NR6COO—, or —NR7CONR8—;
- Ar1 is an iodinated C5-C30 aryl having at least 3 iodine adoms or a C5-C30 heteroaryl;
- having at least 3 iodine adoms;
- each of R2-R8 is independently hydrogen or C1-C10 alkyl;
- and
- n is an integer selected from the range of 1 to 10
- b) a second repeating unit having the formula:
- wherein R9 is an oligomeric polycarbonate.
A polymer composition comprising a crosslinked network formed by polymerization of a monomer mixture comprising
- a) a first monomer having the general structure
- wherein R1 is substituted or unsubstituted C2-C36 alkylene, C2-C36 cycloalkylene, C2-C36 alkenylene, C2-C36 cycloalkenylene, C2-C36 alkynylene, C5-C36 arylene, or C5-C36 heteroarylene;
- L1 is a —(CH2)n—, —(HCCH)n—, —O—, —S—, —SO—, —SO2—, —SO3—, —OSO2—, —NR2—, —CO—, —COO—, —OCO—, —OCOO—, —CONR3—, —NR4CO—, —OCONR5—, —NR6COO—, or —NR7CONR8—;
- Ar1 is an iodinated C5-C30 aryl having at least 3 iodine atoms or C5-C30 heteroaryl having at least 3 iodine atoms;
- and
- each of R2-R8 is independently hydrogen or C1-C10 alkyl;
- n is an integer selected from the range of 1 to 10
- b) a second monomer having the general structure
- R9 is an oligomeric polycarbonate.
A method for making a polymer composition comprising a crosslinked network, the method comprising the steps of:
- a) forming a monomer mixture comprising
- a first monomer having the general structure
- wherein R1 is substituted or unsubstituted C2-C36 alkylene, C2-C36 cycloalkylene, C2-C36 alkenylene, C2-C36 cycloalkenylene, C2-C36 alkynylene, C5-C36 arylene, or C5-C36 heteroarylene;
- L1 is a —(CH2)n—, —(HCCH)n—, —O—, —S—, —SO—, —SO2—, —SO3—, —OSO2—, —NR2—, —CO—, —COO—, —OCO—, —OCOO—, —CONR3—, —NR4CO—, —OCONR5—, —NR6COO—, or —NR7CONR8—;
- Ar1 is an iodinated C5-C30 aryl having at least 3 iodine atoms or C5-C30 heteroaryl having at least 3 iodine atoms;
- and
- each of R2-R8 is independently hydrogen or C1-C10 alkyl;
- n is an integer selected from the range of 1 to 10
- a second monomer having the general structure
- R9 is an oligomeric polycarbonate and a free radical initiator;
- and
- b) polymerizing the monomer mixture.
Dependencies are inferred from the claim text.