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US 9,061,966 B2Granted
Cyclopropylamine inhibitors of oxidases
AssigneeOryzon Genomics, S.A.
InventorsJulio Castro-Palomino Laria, Matthew Colin Thor Fyfe, Marc Martinell Pedemonte, Alberto Ortega Muñoz, Núrla Valls Vidal
Life of this patent
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Abstract
The invention relates to cyclopropylamine compounds, in particular the compounds of Formula (I) as described and defined herein, and their use in therapy, including, e.g., the treatment or prevention of cancer.
Claims22
A compound of Formula (I):
- wherein;
- E is —X3═X4—;
- one of X1, X2, X3, and X4 is N and the other ones of X1, X2, X3, and X4 are each independently C(R2);
- L1 is —NH—CH2—;
- G is phenyl, indolyl, or indazolyl;
- each R1 is independently chosen from alkyl, alkenyl, alkynyl, cyclyl, -L2 cyclyl, -L2-amino, -L2-hydroxyl, amino, amide, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, hydroxyl, alkoxy, urea, carbamate, acyl, and carboxyl;
- each R2 is —H;
- each L2 is independently chosen from alkylene and heteroalkylehe;
- and
- n is 0, 1, 2, 3, 4 or 5;
- or a pharmaceutically acceptable salt or solvate thereof.
8 more elements
A compound of Formula (I):
- wherein:
- E is —X3═X4—;
- one of X1, X2, X3, and X4 is N and the other ones of X1, X2, X3, and X4 are each independently C(R2);
- L1 is —NH— or —NH—CH2—;
- G is phenyl, indolyl, or indazolyl;
- each R1 is independently chosen from alkyl, alkenyl, alkynyl, cyclyl, -L2-cyclyl, -L2-amino, -L2-hydroxyl, amino, amido, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, hydroxyl, alkoxy, urea, carbamate, acyl, and carboxyl;
- each R2 is —H;
- each L2 is independently chosen from alkylene and heteroalkylene;
- and
- n is 0, 1, 2, 3, 4 or 5;
- or a pharmaceutically acceptable salt or solvate thereof.
8 more elements
A compound of Formula (I):
- wherein:
- E is —X3═X4—;
- one of X1, X2, X3, and X4 is N or C(R2) and the other ones of X1, X2, X3,
- and X4 are each independently C(R2);
- L1 is —NH— or —NH—CH2—;
- G is indolyl or indazolyl;
- each R1 is independently chosen from alkyl, alkenyl, alkynyl, cyclyl, -L2-cyclyl, -L2-amino, -L2-hydroxyl, amino, amido, nitro, halo, haloalkyl, haloalkoxy, cyano, sulfinyl, sulfonyl, sulfonamide, hydroxyl, alkoxy, urea, carbamate, acyl, and carboxyl;
- each R2 is —H;
- each L2 is independently chosen from alkylene and heteroalkylene;
- and
- n is 0, 1, 2, 3, 4 or 5;
- or a pharmaceutically acceptable salt or solvate thereof.
9 more elements
Dependencies are inferred from the claim text.