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US 9,061,903 B2Granted
Sulfonate modified nanocrystals
AssigneeLife Technologies Corporation
InventorsEric Tulsky, Eric Welch, Bruce Branchaud, John Mauro, Imad Naasani
Life of this patent
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Abstract
A nanoparticle having one or more phosphonates or phosphinate ligands on their surface can be converted into nanoparticles with sulfonate ligands on their surface, by contacting the phosphonate-containing nanoparticles with a silylsulfonate reagent. Such nanoparticles are activated toward reactions with nucleophilic groups; thus the method provides activated nanoparticles, and methods of making and using them to produce modified nanoparticles.
Claims26
A population of nanoparticles, comprising:
- a plurality of nanoparticles dispersed in an organic solvent, wherein each nanoparticle includes a nanocrystal core including a first semiconductor material, a shell including a second semiconductor material, and an outer layer comprising ligands that each comprise a sulfonate, nitrate, borate, or fluorous anion group, wherein the anion group is bound to one or more metal atoms of the second semiconductor material at the surface of the shell, wherein if the ligand comprises sulfonate, then the sulfonate is selected from the group consisting of trifluoromethanesulfonate (triflate), fluoromethanesulfonate, methanesulfonate (mesylate), nitrophenylsulfonate (nosylate), trifluorethylsulfonate, phenylsulfonate (besylate), and toluenesulfonate (tosylate).
Dependencies are inferred from the claim text.