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US 9,061,073 B2Granted
Antibody-light fusion products for cancer therapeutics
AssigneeThe University of Chicago
InventorYang-Xin Fu
Life of this patent
Estimating the term…
Abstract
Antibody-LIGHT fusion products or conjugates stimulate immunity against tumors and eradicate metastases. Tumor-specific antibodies coupled with LIGHT effectively target metastatic tumors and reduces cancer metastases.
Claims3
A composition comprising a fragment of a protease resistant LIGHT protein in combination with an agent that specifically recognizes a tumor cell, wherein the LIGHT protein and agent are not physically linked, and wherein the fragment is capable of being stably present on a tumor cell surface and is sufficient to stimulate cytotoxic T-lymphocytes against tumor cells.
Dependencies are inferred from the claim text.