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US 9,061,059 B2Granted
Modified polynucleotides for treating protein deficiency
AssigneeModerna Therapeutics, Inc.
InventorsTirtha Chakraborty, Antonin de Fougerolles, Ron Weiss
Life of this patent
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Abstract
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Claims16
A method of producing a polypeptide of interest in a mammalian cell or tissue comprising contacting said mammalian cell or tissue with an mRNA having a 3′ untranslated region and a 5′ untranslated region, wherein said mRNA encodes heparan-alpha-glucosaminide N-acetyltransferase (SEQ ID NO:
- 48935), and wherein said mRNA comprises a coding region, said coding region having at least 85% identity to SEQ ID NO:
- 84333.
An mRNA encoding heparan-alpha-glucosaminide N-acetyltransferase (SEQ ID NO:
- 48935), said mRNA having a 3′ untranslated region and a 5′ untranslated region and wherein said mRNA comprises a coding region, said coding region having at least 85% identity to SEQ ID NO:
- 84333.
Dependencies are inferred from the claim text.