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US 9,061,008 B2Granted
Hepatitis B antiviral agents
AssigneeNovira Therapeutics, Inc.
InventorsGeorge D. Hartman, Osvaldo A. Flores
Life of this patent
Estimating the term…
Abstract
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
Claims18
A compound of Formula IV:
- or pharmaceutically acceptable salts thereof;
- wherein
- R4 is H
- wherein each R5 is independently selected at each occurrence from the group consisting of CH3, C1-C6 alkoxy, halo, —CN, —NO2, —C1-C6 haloalkyl, —C1-C6 dihaloalkyl and —C1-C6 trihaloalkyl;
- R10 is OH, C1-C6 alkyl, or halo
- R11 is a bond or C1-C3 alkylene,
- R2 is independently selected at each occurrence from the group consisting of halo and
- w is 1 or 2;
- each occurrence of x is independently selected from the group consisting of 0, 1, and 2;
- each occurrence of y is independently selected from the group consisting of 1, 2, and 3;
- and
- each occurrence of z is independently selected from the group consisting of 0, 1, 2, and 3.
9 more elements
A compound of Formula IVb:
- and pharmaceutically acceptable salts thereof;
- wherein G1 is independently selected at each occurrence from CH3, OCH3, halo, CF3, CCl3, CH2C1, CCl2H, CF2H, CH2F, and CF3;
- G2 is H, C1-C4 alkyl, or halo;
- G3 is OH, CH2OH, or CH2CH2OH;
- G4 is H, OH, halo, or C1-C6 alkyl;
- and
- y is 1, 2, or 3.
4 more elements
Dependencies are inferred from the claim text.