Molecules and methods for treatment and detection of cancer
AssigneeUniversity of Washington
InventorsMary L. Disis, Vivian Goodell, Hailing Lu, Douglas G. McNeel
Life of this patent
Estimating the term…
Abstract
The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the ovary, breast, prostate and colon. The method comprises contacting a cancer cell with an IGF-related molecule of the invention or administering an IGF-related vaccine to the cancer patient. In one embodiment, the molecule is an immunogenic peptide derived from IGFBP-2 or from IGF1 R. The invention additionally provides methods for detecting and treating cancer using IGF-related molecules.
Claims36
An immunogenic peptide comprising an immunogenic fragment of an IGFBP2 polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 and a pharmaceutically acceptable carrier, wherein the immunogenic fragment consists of the amino acid sequence of SEQ ID NO:
- 14.
A nucleic acid molecule encoding an immunogenic peptide comprising an immunogenic fragment of an IGFBP2 polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 and a pharmaceutically acceptable carrier, wherein the immunogenic fragment consists of the amino acid sequence of SEQ ID NO:
- 14.
An immunogenic peptide comprising an immunogenic fragment of an IGFBP2 polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 and a pharmaceutically acceptable carrier, wherein the immunogenic fragment consists of the amino acid sequence of SEQ ID NO:
- 16.
A nucleic acid molecule encoding an immunogenic peptide comprising an immunogenic fragment of an IGFBP2 polypeptide comprising the amino acid sequence of SEQ ID NO:
- 1 and a pharmaceutically acceptable carrier, wherein the immunogenic fragment consists of the amino acid sequence of SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.