Hydrogel formulations
AssigneeAscendis Pharma A/S
InventorsUlrich Hersel, Harald Rau, Robert Schnepf, Dirk Vetter, Thomas Wegge
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Abstract
A polymeric prodrug composition including a hydrogel, a biologically active moiety and a reversible prodrug linker. The prodrug linker covalently links the hydrogel and the biologically active moiety at a position and the hydrogel has a plurality of pores with openings on its surface. The diameter of the pores is larger than that of the biologically active moiety at least at all points of the pore between at least one of the openings and the position of the biologically active moiety.
Claims23
A mesoporous hydrogel-biologically active moiety conjugate prepared by a process comprising the steps of:
- synthesizing the mesoporous hydrogel, wherein the mesoporous hydrogel comprises backbone and crosslinking moieties, wherein each backbone moiety is linked with at least one other backbone moiety via several crosslinking moieties and wherein the crosslinking moieties comprise biodegradable bonds;
- and
- after completing all said synthesizing
- covalently connecting a prodrug linker to the mesoporous hydrogel which prodrug linker forms a reversible linkage to the biologically active moiety;
- and
- conjugating a biologically active moiety to the prodrug linker;
- wherein the connecting and the conjugating can be carried out in either order.
Dependencies are inferred from the claim text.