Inhibitors against endosomal/lysosomal enzymes
AssigneeUniversity Court of the University of Dundee
InventorsColin Watts, Sander Van Kasteren
Life of this patent
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Abstract
The present invention relates to a multi-functional protease inhibitor, which may be conjugated to various molecules. The present invention also relates to uses of the protease inhibitor and conjugates thereof.
Claims23
A multi-functional protease inhibitor conjugate molecule comprising a cystatin moiety and pepstatin A moiety, or a physiologically acceptable salt, solvate, ester, or amide thereof.
A method of treatment of a disease selected from the group consisting of:
- cancer, inflammatory disease, autoimmune diseases, parasitic disease, galactosialidosis, and Gaucher's disease, said method comprising administering to a subject a pharmaceutical formulation comprising a multi-functional protease inhibitor conjugate molecule comprising a cystatin moiety and pepstatin A moiety, or a physiologically acceptable salt, solvate, ester, or amide thereof.
A vaccine comprising a multi-functional protease inhibitor conjugate molecule comprising a cystatin moiety and pepstatin A moiety, or a physiologically acceptable salt, solvate, ester, or amide thereof.
A method of wound healing, comprising administering to a subject a pharmaceutical formulation comprising a multi-functional protease inhibitor conjugate molecule comprising a cystatin moiety and pepstatin A moiety, or a physiologically acceptable salt, solvate, ester, or amide thereof, together with one or more growth factors.
Dependencies are inferred from the claim text.