Amyloid β-protein-specific production-inhibiting polypeptide
AssigneeThe Doshisha
InventorsYasuo Ihara, Satoru Funamoto, Toru Sasaki
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Abstract
A primary object of the present invention is to develop a compound that specifically inhibits the production of Aβ protein and serves as an active ingredient of a drug to treat and/or prevent Alzheimer's disease. This object can be achieved by a polypeptide having the amino acid sequence represented by any one of SEQ ID NOs: 1, 13, 14, and 22, that binds to the N-terminal region of βCTF; a γ-secretase activity inhibitor containing the polypeptide; β-secretase activity inhibitor; Aβ protein production inhibitor; and an agent for treating and/or preventing Alzheimer's disease.
Claims15
A polypeptide having the amino acid sequence of any one of SEQ ID NOs:
- 1, 13, 14, and 22 wherein the polypeptide binds to the N-terminal region of βCTF.
A γ-secretase activity inhibitor comprising a polypeptide having the amino acid sequence of SEQ ID NO:
- 3.
A β-secretase activity inhibitor comprising a polypeptide having the amino acid sequence of SEQ ID NO:
- 6.
An Aβ protein production inhibitor comprising a polypeptide having the amino acid sequence of SEQ ID NO:
- 6.
A polypeptide having the amino acid sequence of SEQ ID NO:
- 13 wherein the polypeptide binds to the N-terminal region of βCTF.
A polypeptide having the amino acid sequence of SEQ ID NO:
- 14 wherein the polypeptide binds to the N-terminal region of βCTF.
A polypeptide having the amino acid sequence of SEQ ID NO:
- 22 wherein the polypeptide binds to the N-terminal region of βCTF.
A method for treating Alzheimer's disease in a subject in need thereof, comprising administration of a polypeptide having the amino acid sequence of SEQ ID NOs:
- 3, 4, 6, 14 or 22 to the subject, thereby treating the subject.
Dependencies are inferred from the claim text.