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US 9,045,517 B2Granted
Glycosylated aminocoumarins and methods of preparing and uses of same
AssigneeUniversity College London
InventorMin Yang
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Abstract
There is provided a method of glycosylating an aminocoumarin compound comprising conjugating a sugar to the 4′-OH position of the core of the aminocoumarin compound. Also provided is an aminocoumarin compound glycosylated at the 4′-OH position of the core of the aminocoumarin compound. Further aspects of this invention provide this compound for use in therapy, more particularly for use as an antibiotic, or in anticancer treatment.
Claims5
An aminocoumarin compound glycosylated at the 4-OH position of the core of the aminocoumarin compound having the formula
- wherein R1, R3 and R4 are each independently selected from H, OH, C1-20 alkyl, C1-20 alkenyl, amino, or a halogen;
- R2 is an optionally substituted sugar moiety;
- R5 is selected from aryl, heteroaryl, C1-20 alkyl, C1-20 alkenyl, H, or C(═O)R6,
- wherein R6 is selected from the same groups as R5 or is halo, amino, or OH;
- and
- wherein X is a sugar selected from glucose and galactose.
3 more elements
Dependencies are inferred from the claim text.