Geranyl geranyl acetone (GGA) derivatives and compositions thereof

A compound of Formula (I):

• or pharmaceutically acceptable salt thereof, wherein
• n1 is 1 or 2;
• Q1 is —(C═O)—, —(C═S)—, or —S(O2)—;
• Q2 is —NR7R8;
• each R1 and R2 are independently C1-C6 alkyl, or R1 and R2 together with the carbon atom they are attached to form a C5-C7 cycloalkyl ring optionally substituted with 1-3 C1-C6 alkyl groups;
• each of R3, R4, and R5 independently are C1-C6 alkyl;
• R6 is:
• C1-C6 alkyl, optionally substituted with —CO2H or an ester thereof, C1-C6 alkoxy, oxo, —OH, —CR═CR2, —C≡CR, C3-C10 cycloalkyl, C3-C8 heterocyclyl, C6-C10 aryl, C2-C10heteroaryl, wherein each R independently is hydrogen or C1-C6 alkyl;
• C3-C10 cycloalkyl;
• C3-C8 heterocyclyl;
• C6-C10 aryl;
• or
• C2-C10 heteroaryl, provided that when n1 is 2, and one of R7 and R8 is hydrogen, R6 excludes C2-C10 heteroaryl
• wherein each cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with 1-3 alkyl groups;
• —CF3, 1-3 halo;
• 1-3 nitro groups;
• 1-3 C1-C6 alkoxy groups;
• —CO-phenyl;
• or —NR18R19;
• each R7 and R8 are independently hydrogen or defined as R6, provided that if n1 is 1 and one of R7 and R8 is hydrogen, the other excludes hydrogen
• each R18 and R19 independently is hydrogen;
• C1-C6 alkyl, optionally substituted with —CO2H or an ester thereof, C1-C6 alkoxy, oxo, —CR═CR2, —C≡CR, C3-C10 cycloalkyl, C3-C8 heterocyclyl, C6-C10 aryl, or C2-C10 heteroaryl, wherein each R independently is hydrogen or C1-C6 alkyl;
• C3-C10 cycloalkyl;
• C3-C8 heterocyclyl;
• C6-C10 aryl;
• or C2-C10 heteroaryl;
• wherein each cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with 1-3 alkyl groups, optionally substituted with 1-3 halo, or where R18 and R19 together with the nitrogen atom they are attached to form a 5-7 membered heterocycle.