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US 9,044,531 B2Granted
Vascular closure device
AssigneeCordis Corporation
InventorsVipul Bhupendra Dave, Chao Chin-Chen
Life of this patent
Estimating the term…
Abstract
A biocompatible material may be configured into any number of implantable medical devices including a vascular closure device. The vascular closure device includes a fibrous structure formed from at least one randomly oriented fiber, the randomly oriented fiber comprising at least one polymer, and at least one agent, in therapeutic dosage, incorporated into at least one of the fibrous structure and the at least one randomly oriented fiber.
Claims4
A vascular closure device comprising:
- a preshaped, cylindrical fibrous plug formed prior to delivery from a nonwoven fabric of at least one randomly oriented and entangled fiber, the thickness of the nonwoven fabric ranging from about 0.25 to 2 mm, the basis weight of the nonwoven fabric ranging from about 0.01 to 0.2 g/in2, the at least one randomly oriented fiber having a density from about 120 to about 150 denier and a tenacity from about 3 to about 7 g/denier, the cylindrical fibrous plug being configured for occluding blood flow from a puncture and sealing a wound in a tract of a puncture wound, the fibrous plug having a definite cylindrical shape and volume ex vivo, the randomly oriented fiber comprising at least one polymer;
- and
- at least one agent, in therapeutic dosage, dispersed in the fiber matrix of the at least one randomly oriented fiber, and configured for controlled elution therefrom, the at least one agent comprises an agent selected from a group consisting of anti-proliferative agents, anti-thrombogenic agents, anti-restenotic agents, anti-viral agents, anti-inflammatory agents, cytostatic agents, immunosuppressive agents, anti-calcification agents, anti-encrustation agents, statins, hormones, anti-cancer agents, anti-coagulants, anti-migratory agents, tissue growth promoting agents, heparin, and combinations thereof.
Dependencies are inferred from the claim text.