# US 9,040,904 B2 · Analysis method, adhesive tape, and pen > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,040,904 B2 - Document ID: US9040904B2 - Status: Granted - Kind: B2 - Application number: 13/877,360 - Filed: 2011-10-05 - Published: 2013-07-25 - Granted: 2015-05-26 - Earliest claimed: 2010-10-07 - Assignees: Shiseido Company, Ltd. - Applicants: Haruo Shimada; Yoshimasa Nakatani; Yuka Noritake - Inventors: Haruo Shimada; Yoshimasa Nakatani; Yuka Noritake - Web page: https://patentgrep.com/patent/US9040904B2 ## CPC - H01J 49/0027: {Methods for using particle spectrometers} - H01J 49/0009: {Calibration of the apparatus} - H01J 49/14: using particle bombardment, e.g. ionisation chambers - H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H) ## Abstract There is provided an analysis method including the steps of forming a layer including a calibration reagent, that can generate ions by using a DART ion source apparatus, in a predetermined area of a sample, and performing mass spectrometry on the ions generated from an area of the sample including the layer by using DART or DESI while moving the sample having the layer formed therein. ## Claims ### Claim 1 An analysis method comprising the steps of: forming a layer including a calibration reagent, that can generate ions by using a DART ion source apparatus, in a predetermined area of a sample; and performing mass spectrometry on the ions generated from an area of the sample including the layer by using DART or DESI while moving the sample having the layer formed therein; wherein the layer including the calibration reagent is formed in a straight-linear shape on a surface of the sample, wherein the straight-linear shape of the layer including the calibration reagent is elongated in a direction orthogonal to a direction in which the sample is moved. ### Claim 2 (depends on 1) The analysis method as claimed in claim 1, wherein the layer including the calibration reagent is formed by adhering an adhesive tape including the calibration reagent. ### Claim 3 (depends on 1) The analysis method as claimed in claim 1, wherein the layer including the calibration reagent is formed by using a pen filled with an ink including the calibration reagent. ### Claim 4 (depends on 1) The analysis method as claimed in claim 1, wherein the calibration reagent includes one or both of polyethylene glycol having a mass spectrum including equally spaced peaks (PEG 60-PEG 2000) or a fatty acid having a carbon number of 4-36. ### Claim 5 (depends on 1) The analysis method as claimed in claim 1, wherein the layer including the calibration reagent extends in a direction that is parallel to the surface of the sample. ### Claim 6 (depends on 5) The analysis method as claimed in claim 5, wherein the direction that is parallel to the surface of the sample includes an X-axis direction of the sample. ### Claim 7 (depends on 1) The analysis method as claimed in claim 1, further comprising a step of: applying an external pharmaceutical preparation to another predetermined area of the sample; wherein the layer including the calibration reagent is formed, so that an interval of an intermediate point between the predetermined area and the another predetermined area becomes a predetermined length. ### Claim 8 An adhesive tape comprising: a calibration reagent that can generate ions by using a DART ion source apparatus; wherein the calibration reagent is formed in a layer of a predetermined area of a sample, wherein the layer including the calibration reagent is formed in a straight-linear shape on a surface of the sample, wherein the straight-linear shape of the layer including the calibration reagent is elongated in a direction orthogonal to a direction in which the sample is moved. ### Claim 9 (depends on 8) The adhesive tape as claimed in claim 8, wherein the calibration reagent includes one or both of polyethylene glycol having a mass spectrum including equally spaced peaks (PEG 60-PEG 2000) or a fatty acid having a carbon number of 4-36. ### Claim 10 (depends on 8) The adhesive tape as claimed in claim 8, wherein the layer including the calibration reagent extends in a direction that is parallel to the surface of the sample. ### Claim 11 (depends on 10) The adhesive tape as claimed in claim 10, wherein the direction that is parallel to the surface of the sample includes an X-axis direction of the sample. ### Claim 12 (depends on 8) The adhesive tape as claimed in claim 8, wherein the sample includes another predetermined area to which an external pharmaceutical preparation is applied, wherein the layer including the calibration reagent is formed, so that an interval of an intermediate point between the predetermined area and the another predetermined area becomes a predetermined length. ### Claim 13 A pen comprising: an ink filled in the pen and including a calibration reagent that can generate ions by using a DART ion source apparatus; wherein the calibration reagent is formed in a layer of a predetermined area of a sample, wherein the layer including the calibration reagent is formed in a straight-linear shape on a surface of the sample, wherein the straight-linear shape of the layer including the calibration reagent is elongated in a direction orthogonal to a direction in which the sample is moved. ### Claim 14 (depends on 13) The pen as claimed in claim 13, wherein the calibration reagent includes one or both of polyethylene glycol having a mass spectrum including equally spaced peaks (PEG 60-PEG 2000) or a fatty acid having a carbon number of 4-36. ### Claim 15 (depends on 13) The pen as claimed in claim 13, wherein the layer including the calibration reagent extends in a direction that is parallel to the surface of the sample. ### Claim 16 (depends on 15) The pen as claimed in claim 15, wherein the direction that is parallel to the surface of the sample includes an X-axis direction of the sample. ### Claim 17 (depends on 13) The pen as claimed in claim 13, wherein the sample includes another predetermined area to which an external pharmaceutical preparation is applied, wherein the layer including the calibration reagent is formed, so that an interval of an intermediate point between the predetermined area and the another predetermined area becomes a predetermined length.