# US 9,040,747 B2 · Method for producing reduced coenzyme Q10, method for stabilizing same, and composition comprising same

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- Number: US 9,040,747 B2
- Document ID: US9040747B2
- Status: Granted
- Kind: B2
- Application number: 13/501,692
- Filed: 2010-10-15
- Published: 2012-08-16
- Granted: 2015-05-26
- Earliest claimed: 2009-10-16
- Assignees: Kaneka Corporation
- Applicants: Takaaki Jikihara; Takao Yamaguchi; Shiro Kitamura; Yasuyoshi Ueda
- Inventors: Takaaki Jikihara; Takao Yamaguchi; Shiro Kitamura; Yasuyoshi Ueda
- Web page: https://patentgrep.com/patent/US9040747B2

## CPC

- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/175: Amino acids
- A23P 10/30: Encapsulation of particles, e.g. foodstuff additives
- A61K 9/10: Dispersions; Emulsions
- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61P 17/18: Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00)
- A61P 39/06: Free radical scavengers or antioxidants
- C07C 41/26: by introduction of hydroxy or O-metal groups
- C07C 41/46: Use of additives, e.g. for stabilisation
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A23P: SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

An object of the present invention is to provide a substance characterized by ability to reduce oxidized coenzyme Q10 and ability to stabilize reduced coenzyme Q10, which contains nutrients, has a favorable taste, and is excellent in general versatility, and a method for using the same. The present invention relates to a method for producing reduced coenzyme Q10 comprising reducing oxidized coenzyme Q10 with a particular amino acid. The present invention also relates to a method for stabilizing reduced coenzyme Q10 in the presence of a particular amino acid and a composition stabilized by the method.

## Claims

### Claim 1

A method for producing reduced coenzyme Q10 which comprises reducing oxidized coenzyme Q10 at a reaction temperature or 50° C. or more using an amino acid with a side chain containing a functional group comprising a nitrogen atom and/or an oxygen atom, wherein the amino acid is lysine.

### Claim 2 (depends on 1)

The production method of claim 1, wherein the reduction reaction is carried out in the presence of an organic solvent, a fat, an oil, water, or a mixture thereof.

### Claim 3 (depends on 2)

The production method of claim 2, wherein the organic solvent is at least one member selected from the group consisting of alcohols, fatty acids, and terpenes.

### Claim 4 (depends on 1)

The production method of claim 1, wherein the reduction reaction is allowed to take place in a preparation selected from the group consisting of capsules, tablets, syrups, and dosage form for oral administration.

### Claim 5 (depends on 4)

The production method of claim 4, wherein the preparation is in the form of a capsule.

### Claim 6 (depends on 1)

The production method of claim 1, wherein the reduction reaction is carried out under a deoxygenated atmosphere.

### Claim 7 (depends on 1)

The production method of claim 1, wherein the reduction reaction is carried out in the presence of a solvent selected from the group consisting of alcohols, terpenes, plant fats and oils, medium-chain triglycerides (MCT) and mixtures thereof.