# US 9,040,686 B2 · Coating agent comprising hydroxyalkyl cellulose

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- Number: US 9,040,686 B2
- Document ID: US9040686B2
- Status: Granted
- Kind: B2
- Application number: 13/392,298
- Filed: 2010-08-30
- Published: 2012-06-21
- Granted: 2015-05-26
- Earliest claimed: 2009-09-02
- Assignees: Nippon Soda Co., Ltd.
- Applicants: Yusuke Masue
- Inventors: Yusuke Masue
- Web page: https://patentgrep.com/patent/US9040686B2

## CPC

- A61K 47/38: Cellulose; Derivatives thereof
- C08B 11/08: with hydroxylated hydrocarbon radicals; Esters, ethers, or acetals thereof
- C09D 101/284: {with hydroxylated hydrocarbon radicals}
- A61K 9/2866: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C08B: POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21)
- C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D)

## Abstract

A coating agent containing a hydroxyalkyl cellulose in which a content of hydroxyalkoxy groups within the hydroxyalkyl cellulose is within a range of 40 to 50% by mass, preferably a coating agent containing a hydroxyalkyl cellulose in which the content of hydroxyalkoxy groups is within a range of 40 to 50% by mass and also a viscosity of 2% aqueous solution at 20° C. is within a range of 3.0 to 5.9 mPa·s; and a solid preparation coated with the coating agent.

## Claims

### Claim 1

A coating agent comprising:
a solvent consisting of water; and
a hydroxypropyl cellulose in which:
a content of hydroxypropoxy groups within the hydroxypropyl cellulose is within a range of 42 to 48% by mass; and
a viscosity of a 2% aqueous solution of the hydroxypropyl cellulose at 20° C. is within a range of 3.0 to 5.9 mPa·s.

### Claim 2 (depends on 1)

The coating agent according to claim 1, consisting of:
the solvent;
the hydroxypropyl cellulose; and
at least one selected from the group consisting of talc, titanium oxide, ferric oxide yellow, iron sesquioxide, legal pigments, light anhydrous silicic acid, hydrous silicon dioxide, polyethylene glycol, polypropylene glycol, triethyl citrate, glycerol mono-acetate, glycerol di-acetate, glycerol tri-acetate, 1,2-propylene glycol, sucrose, polyvinyl pyrrolidone, dextrose, sorbitol, mannitol, sucrose, polyvinyl pyrrolidone, lactose, starch, sodium starch glycolate, ethyl cellulose, maltodextrins, cellulose acetate phthalate, microcrystalline cellulose, hydroxypropyl methylcellulose, alginates, gum arabic, carboxymethyl cellulose, hydroxyethyl cellulose, and methyl cellulose.

### Claim 3 (depends on 1)

A solid preparation comprising a coating film obtained using the coating agent of claim 1.

### Claim 4 (depends on 3)

The solid preparation according to claim 3, further comprising a plain tablet comprising a drug.

### Claim 5 (depends on 3)

The solid preparation according to claim 3, wherein the solid preparation is a sugar-coated tablet.