# US 9,040,626 B2 · Nanofibers and morphology shifting micelles

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- Number: US 9,040,626 B2
- Document ID: US9040626B2
- Status: Granted
- Kind: B2
- Application number: 13/363,645
- Filed: 2012-02-01
- Published: 2012-06-14
- Granted: 2015-05-26
- Earliest claimed: 2009-08-03
- Assignees: The Regents of the University of California
- Applicants: Miao-Ping Chien; Nathan C. Gianneschi
- Inventors: Miao-Ping Chien; Nathan C. Gianneschi
- Web page: https://patentgrep.com/patent/US9040626B2

## CPC

- C12N 9/96: Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
- A61K 9/0092: {Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes}
- A61K 9/1075: {Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence)}
- A61K 9/5115: {Inorganic compounds}
- C12N 9/22: Ribonucleases {[RNase]; Deoxyribonucleases [DNase]}
- Y10S 977/89: Deposition of materials, e.g. coating, cvd, or ald
- Y10S 977/906: Drug delivery
- Y10S 977/915: Therapeutic or pharmaceutical composition
- Y10S 977/916: Gene therapy
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.

## Claims

### Claim 1

A method of altering a morphology of a micelle from a rod to a sphere, said method comprising, subjecting said micelle to a stimulus wherein said micelle comprises a plurality of aggregated amphiphilic molecules each having a single-strand nucleic acid hydrophilic portion comprising at least one nucleic acid moiety covalently linked to a polymer within said amphiphilic molecules, and a hydrophobic portion, and wherein said stimulus is a single-strand nucleic acid hydrophilic portion binder capable of hybridizing to one of said single-strand nucleic acid hydrophilic portions thereby altering the morphology of said micelle from a rod to a sphere.

### Claim 2 (depends on 1)

The method of claim 1, wherein said single-strand nucleic acid hydrophilic portion is a plurality of nucleic acid moieties.

### Claim 3 (depends on 1)

The method of claim 1, wherein said single-strand nucleic acid binder is a single strand DNA.

### Claim 4 (depends on 1)

The method of claim 1, wherein said single-strand nucleic acid binder is DNA, RNA, PNA or DNA/RNA hybrid.

### Claim 5 (depends on 1)

The method of claim 1, wherein said morphology of said micelle is altered from a rod to a sphere when more than 25% of the nucleic acid moieties of the single-strand nucleic acid hydrophilic portion is hybridized by the single-strand nucleic acid binder.

### Claim 6 (depends on 1)

The method of claim 1, wherein said morphology of said micelle is altered from a rod to a sphere when more than 50% of the nucleic acid moieties of the single-strand nucleic acid hydrophilic portion is hybridized by the single-strand nucleic acid binder.

### Claim 7 (depends on 1)

The method of claim 1, wherein said morphology of said micelle is altered from a rod to a sphere when more than 75% of the nucleic acid moieties of the single-strand nucleic acid hydrophilic portion is hybridized by the single-strand nucleic acid binder.

### Claim 8 (depends on 1)

The method of claim 1, wherein said micelle further comprises a drug or a fluorogenic tag.

### Claim 9 (depends on 8)

The method of claim 8, wherein said drug or said fluorogenic tag is covalently attached to said amphiphilic molecules.

### Claim 10 (depends on 9)

The method of claim 9, wherein said drug or said fluorogenic tag is non-covalently bound to said amphiphilic molecules.

### Claim 11 (depends on 10)

The method of claim 10, wherein said drug or said fluorogenic tag is released or uptaken upon contacting said micelle with a stimulus.

### Claim 12 (depends on 1)

The method of claim 1, wherein said micelle further comprises a contrast agent.

### Claim 13 (depends on 12)

The method of claim 12, wherein said contrast agent is an X-ray reagent, a radiography reagent, a magnetic resonance imaging agent, a quantum dot, a contrast agent nanoparticle, or an ultrasound agent.

### Claim 14 (depends on 13)

The method of claim 13, wherein relaxivity of said contrast agent is altered upon contacting said amphiphilic molecules with a stimulus.

### Claim 15 (depends on 13)

The method of claim 13, wherein said contrast agent is covalently attached to said amphiphilic molecules.

### Claim 16 (depends on 13)

The method of claim 13, wherein said contrast agent is non-covalently bound to said amphiphilic molecules.

### Claim 17 (depends on 13)

The method of claim 13, wherein said contrast agent is released or uptaken upon contacting said micelle with a stimulus.