# US 9,040,592 B2 · Process for preparing 4-cyclohexyl-2-methyl-2-butanol

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- Number: US 9,040,592 B2
- Document ID: US9040592B2
- Status: Granted
- Kind: B2
- Application number: 13/873,343
- Filed: 2013-04-30
- Published: 2013-09-19
- Granted: 2015-05-26
- Earliest claimed: 2010-03-24
- Assignees: BASF SE
- Applicants: BASF SE
- Inventors: Klaus Ebel; Stefan Rüdenauer; Ralf Pelzer; Martin Bock
- Web page: https://patentgrep.com/patent/US9040592B2

## CPC

- C07C 31/1355: {with a six-membered ring}
- A61K 8/34: Alcohols
- A61Q 19/00: Preparations for care of the skin
- C07C 29/19: in six-membered aromatic rings
- C07C 29/20: in a non-condensed rings substituted with hydroxy groups
- C07C 29/44: increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon double or triple bond (C07C29/16 takes precedence)
- C07C 29/80: by distillation
- C07C 33/20: monocyclic
- C11B 9/0034: {the ring containing six carbon atoms}
- C11B 9/0061: {compounds containing a six-membered aromatic ring not condensed with another ring}
- C11D 3/2017: {branched}
- C11D 3/50: Perfumes
- A61K 2800/10: General cosmetic use
- A61Q 13/00: Formulations or additives for perfume preparations (essential oils or perfumes per se C11B9/00)
- C07C 2601/14: The ring being saturated
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C11B: PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES (drying-oils C09F)
- C11D: DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL

## Abstract

The present invention relates to a process for preparing 4-cyclohexyl-2-methyl-2-butanol. The process comprises the following steps: a) reaction of styrene with isopropanol at elevated temperature to obtain 4-phenyl-2-methyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 4-phenyl-2-methyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics.

## Claims

### Claim 1

A composition comprising 2-methyl-4-phenyl-2-butanol and 2-methyl-4-phenyl-2-pentanol.

### Claim 2 (depends on 1)

The composition according to claim 1, in which the weight ratio of 2-methyl4-phenyl-2-butanol to 2-methyl -4-phenyl- 2-pentanol is in the range from 50:1 to 1000:1.

### Claim 3 (depends on 1)

A process for preparing the composition according to claim 1, the process comprising reacting styrene with isopropanol at elevated temperature under conditions under which isopropanol is present under supercritical conditions, the molar ratio of styrene to isopropanol being in the range from 1:10 to 1:130.

### Claim 4 (depends on 3)

The process according to claim 3, wherein at least 80% of the isopropanol is initially charged and at least 80% of the styrene is supplied to the reaction under reaction conditions.

### Claim 5 (depends on 1)

A fragrance which comprises 2-methyl-4-phenyl-2-pentanol or the composition according to claim 1.

### Claim 6 (depends on 1)

A cosmetic composition which comprises 2-methyl-4-phenyl-2-pentanol or the composition according to claim 1.

### Claim 7 (depends on 1)

A washing or cleaning composition which comprises 2-methyl-4-phenyl-2-pentanol or the composition according to claim 1.