# US 9,040,586 B2 · Veterinary compositions for controlling ecto- and endoparasites in bovines, use of these compositions, use of IGR substances associated with microminerals, method for controlling ecto- and endoparasites in bovines and kit

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- Number: US 9,040,586 B2
- Document ID: US9040586B2
- Status: Granted
- Kind: B2
- Application number: 13/648,610
- Filed: 2012-10-10
- Published: 2014-03-06
- Granted: 2015-05-26
- Earliest claimed: 2012-08-28
- Assignees: Champion Farmoquimico Ltda.
- Applicants: Champion Farmoquimico Ltda.
- Inventors: Flávio Alves da Rocha
- Web page: https://patentgrep.com/patent/US9040586B2

## CPC

- A01N 47/34: containing the groups [IMAGE cpc-sch-A01N-0947.gif], e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
- A61K 31/17: having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine (isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64)
- A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof
- A61K 33/18: Iodine; Compounds thereof
- A61K 33/24: Heavy metals; Compounds thereof
- A61K 33/26: Iron; Compounds thereof
- A61K 33/32: Manganese; Compounds thereof
- A61K 33/34: Copper; Compounds thereof
- A61P 33/00: Antiparasitic agents
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Veterinary compositions are described for controlling ecto- and endo-parasites in animals, such as bovine. The compositions contain an IGR compound(s) or a benzoyl substituted urea(s) along with a mineral mix and at least one carrier.

## Claims

### Claim 1

A veterinary composition for controlling ecto- and endoparasites in animals, comprising at least one IGR compound, a micromineral mix comprising each of the microminerals iron, copper, cobalt, manganese, iodine, selenium, chromium, and zinc, and optionally at least one carrier, wherein said veterinary composition comprises from about 20 to about 40 mg of at least one IGR compound, from about 50 to about 80 mg of iron, from about 3 to about 7 mg of copper, from about 0.5 to about 4.5 mg of cobalt, from about 1 to about 5 mg of manganese, from about 2 to about 6 mg of iodine, from about 0.1 to about 0.5 mg of selenium, from about 0.1 to about 0.5 mg of chromium, and from about 0.1 to about 2 mg of zinc per 103 mg combined weight of the at least one IGR compound, iron, copper, cobalt, manganese, iodine, selenium, chromium, and zinc in the composition.

### Claim 2

A veterinary composition for controlling ecto- and endoparasites in animals, comprising a) at least one benzoyl substituted urea, according to formula I:
where:
R1 and R2, which are the same or different, is an halogen atom or a methyl group,
R3 is an halogen atom or an alkyl group containing 1 to 15 carbon atoms, optionally halogenated;
b) a micromineral mix comprising each of the microminerals iron, copper, cobalt, manganese, iodine, selenium, chromium, and zinc; and
c) optionally, at least one carrier acceptable to veterinary use,
wherein said veterinary composition comprises from about 20 to about 40 mg of at least one benzoyl substituted urea according to formula I, from about 50 to about 80 mg of iron, from about 3 to about 7 mg of copper, from about 0.5 to about 4.5 mg of cobalt, from about 1 to about 5 mg of manganese, from about 2 to about 6 mg of iodine, from about 0.1 to about 0.5 mg of selenium, from about 0.1 to about 0.5 mg of chromium, and from about 0.1 to about 2 mg of zinc per 103 mg combined weight of the at least one benzoyl substituted urea, iron, copper, cobalt, manganese, iodine, selenium, chromium, and zinc in the composition.

### Claim 3 (depends on 2)

The veterinary composition according to claim 2, wherein R1 and R2 are fluorine atoms and R3 is a chlorine atom.

### Claim 4 (depends on 1)

The veterinary composition according to claim 1, wherein the IGR compound is 1-(4-chloridephenyl)-3-(2,6-difluorobenzoyl)urea.

### Claim 5 (depends on 1)

The veterinary composition according to claim 1, wherein the IGR compound is diflubenzuron, cyromazine, triflumuron, methoprene, S-methoprene, hydroprene, S-hydroprene, fluazuron, dicyclanyl, azadirachtin, lufenuron, flufenuxuron, nitenpiram, imidacloprid, teflubenzuron, noviflumuron, methoxyfenozide, pyriproxyfen, tebufenozide, fenoxycarb, buprofezin, hexaflumuron, a chemically active derivative thereof, or any combinations thereof.

### Claim 6 (depends on 1)

The veterinary composition according to claim 1, wherein said carrier is a nonylphenol ethoxylate, sodium lignosulphonate, dodecyl benzene sulphonate, octylphenol ethoxylate, sodium polysorbate, potassium polysorbate, citric pectin, sodium laurel sulphate, micronized silica, kaolin, or talc, or any combinations thereof.

### Claim 7 (depends on 1)

The veterinary composition according to claim 1 further comprising at least one thickening agent, at least one stabilizer, at least one flavoring agent, at least one anticoagulant, or at least one preservative, or any combinations thereof.

### Claim 8 (depends on 1)

A method to control ecto- and endo-parasites, comprising administering the veterinary composition of claim 1 to an animal in an amount effective to control said ecto- and endo-parasites.

### Claim 9 (depends on 2)

A method to control ecto- and endo-parasites, comprising administering the veterinary composition of claim 2 to an animal in an amount effective to control said ecto- and endo-parasites.

### Claim 10 (depends on 1)

A kit for the control method of ectoparasites, comprising at least the veterinary composition of claim 1 in at least one container, a quantity dosing device, and optionally instructions for administering said composition.

### Claim 11 (depends on 1)

A method for controlling ecto- and endoparasites and enhancing zootechnical performance, comprising administering, orally, through feed or nutritional supplementation, the veterinary composition of claim 1 whereby control of ecto- and endoparasites is achieved.

### Claim 12 (depends on 1)

The veterinary composition of claim 1, wherein said veterinary composition does not comprise of macrominerals.

### Claim 13 (depends on 1)

The veterinary composition of claim 1, wherein said veterinary composition comprises macrominerals in an amount of less than 0.0001% by weight, based on the total weight of the composition.

### Claim 14 (depends on 1)

The veterinary composition of claim 1, wherein said veterinary composition does not comprise thickening agents.

### Claim 15 (depends on 1)

The veterinary composition of claim 1, wherein said veterinary composition does not comprise thickening agents, stabilizers, flavoring agents, anticoagulants, preservatives and adjuvants.

### Claim 16 (depends on 1)

The veterinary composition of claim 1, wherein said veterinary composition does not comprise thickening agents and carriers.