# US 9,040,583 B2 · Treatment of disorders associated with G protein-coupled receptor 35 (GPR35)

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- Number: US 9,040,583 B2
- Document ID: US9040583B2
- Status: Granted
- Kind: B2
- Application number: 13/386,288
- Filed: 2010-07-14
- Published: 2012-05-17
- Granted: 2015-05-26
- Earliest claimed: 2009-07-22
- Assignees: Temple University of the Commonwealth System of Higher Education; Duke University; Research Triangle Institute
- Applicants: Mary E. Abood; Pingwei Zhao; Lawrence S. Barak; Herbert H. Seltzman
- Inventors: Mary E. Abood; Pingwei Zhao; Lawrence S. Barak; Herbert H. Seltzman
- Web page: https://patentgrep.com/patent/US9040583B2

## CPC

- A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A61K 31/191: having two or more hydroxy groups, e.g. gluconic acid
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.

## Claims

### Claim 1

A method of providing neuroprotection in case of stroke or ischemia to a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of a compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
R1 and R2 are independently F, Cl, Br or I; and,
n is 0 or 1;
wherein said pharmaceutically acceptable salt comprises a cationic counterion which itself does not provide therapeutically useful neuroprotection in case of stroke or ischemia to said subject.

### Claim 2 (depends on 1)

The method of claim 1, wherein said compound of Formula (I) is 7,7′-dibromo-pamoic acid or a pharmaceutically acceptable salt thereof.

### Claim 3

A method of providing neuroprotection in case of stroke or ischemia to a subject in need thereof, said method comprising administering to said subject a therapeutically effective amount of 1,1′-binaphtyl-2,2′-diol -3,3′-dicarboxylic acid, or a pharmaceutically acceptable salt thereof wherein said pharmaceutically acceptable salt comprises a cationic counterion which itself does not provide therapeutically useful neuroprotection in case of stroke or ischemia to said subject.