# US 9,040,582 B2 · Formulation and method to induce a deep state of relaxation

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- Number: US 9,040,582 B2
- Document ID: US9040582B2
- Status: Granted
- Kind: B2
- Application number: 13/464,425
- Filed: 2012-05-04
- Published: 2013-08-15
- Granted: 2015-05-26
- Earliest claimed: 2011-05-04
- Applicants: Raymond M. Keller
- Inventors: Raymond M. Keller
- Web page: https://patentgrep.com/patent/US9040582B2

## CPC

- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A23L 33/15: Vitamins
- A23L 33/175: Amino acids
- A61K 9/0073: {Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; (nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M)}
- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A61K 31/4045: Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A61M 15/06: Inhaling appliances shaped like cigars, cigarettes or pipes
- A61M 16/109: {the humidifying liquid or the beneficial agent}
- A61M 21/02: for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia (for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021)
- A61P 25/00: Drugs for disorders of the nervous system
- C07C 229/36: with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
- C07D 209/16: Tryptamines
- C07D 209/20: substituted additionally by nitrogen atoms, e.g. tryptophane
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61M 2205/36: related to heating or cooling
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A relaxation formulation structured to induce a deep state of relaxation in a person comprises amounts of tryptophan, melatonin, vitamin B3, and vitamin B6. Another relaxation formulation also includes an amount of tyrosine, and yet another formulation includes an amount of vitamin B12. At least one embodiment of a relaxation formula comprises a physiologically effective amount of gamma-aminobutyric acid (“GABA”). A delivery system is provided to facilitate administration of the relaxation formulation to a person. The delivery system may include an edible high carbohydrate matrix, such as a chocolate brownie. Alternatively, the delivery system may comprise an inert vaporizable compound to allow the components of the relaxation formulation to be inhaled directly into the lungs of a person. Other delivery systems include an aqueous sublingual spray and a beverage.

## Claims

### Claim 1

A relaxation formulation structured to induce a deep state of relaxation in a person, said relaxation formulation comprising:
tryptophan, tyrosine, melatonin, and at least one vitamin selected from the group consisting of vitamin B3, vitamin B6, and vitamin B12,
wherein a unit dosage of said relaxation formulation comprises:
an amount of L-tryptophan in a range of about 250 to 3,000 milligrams,
an amount of tyrosine in a range of about 25 to 300 milligrams,
an amount of melatonin in a range of about 1 to 10 milligrams,
an amount of vitamin B3 in a range of about 3 to 36 milligrams,
an amount of vitamin B6 in a range of about 5 to 75 milligrams, and
an amount of vitamin B12 in a range of about 1 to 10 micrograms, and
wherein said amount of tyrosine relative to said amount of L-tryptophan is in a ratio of about 10:1 of L-tryptophan:tyrosine.

### Claim 2 (depends on 1)

The relaxation formulation as recited in claim 1 further comprising a delivery system.

### Claim 3 (depends on 2)

The relaxation formulation as recited in claim 2 wherein said delivery system comprises a chocolate brownie having a net weight of about 2 ounces.

### Claim 4 (depends on 2)

The relaxation formulation as recited in claim 2 wherein said delivery system comprises an inert vaporizable compound.

### Claim 5

A method for inducing a deep state of relaxation in a person, wherein the method comprises the steps of:
administering at least a portion of a unit dosage of a relaxation formulation to the person, wherein the relaxation formulation comprises a predetermined amount of each of tryptophan, melatonin, vitamin B3, and vitamin B6, and
administering at least the portion of the relaxation formulation to the person via a delivery system, wherein the delivery system comprises an aqueous sublingual spray.