# US 9,040,570 B2 · Compounds for anti-fungal treatment

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- Number: US 9,040,570 B2
- Document ID: US9040570B2
- Status: Granted
- Kind: B2
- Application number: 13/695,185
- Filed: 2011-04-29
- Published: 2013-07-04
- Granted: 2015-05-26
- Earliest claimed: 2010-04-30
- Assignees: University of Rochester
- Applicants: Damian J. Krysan
- Inventors: Damian J. Krysan
- Web page: https://patentgrep.com/patent/US9040570B2

## CPC

- A61K 31/4196: 1,2,4-Triazoles
- A61K 31/135: having aromatic rings {, e.g. ketamine, nortriptyline (methadone A61K31/137)}
- A61K 31/138: Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine (atenolol A61K31/165; pindolol A61K31/404; timolol A61K31/5377)
- A61K 31/41: having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/10: Antimycotics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided are methods of treating or preventing a fungal infection in a subject. The methods comprise selecting a subject with or at risk of developing a fungal infection and administering to the subject a therapeutically effective amount of toremifene and fluconazole or derivatives thereof.

## Claims

### Claim 1

A method of treating a fungal infection in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of toremifene and fluconazole, wherein the fungal infection is caused by Cryptococcus neoformans.

### Claim 2 (depends on 1)

The method of claim 1, wherein the method further comprises selecting a subject with a fungal infection.

### Claim 3 (depends on 1)

The method of claim 1, wherein the subject is administered a dose of toremifene, wherein the dose ranges from about 2 micrograms per milliliter (μg/ml) to about 20 μg/ml.

### Claim 4 (depends on 3)

The method of claim 3, wherein the subject is administered a 4 μg/ml dose of toremifene.

### Claim 5 (depends on 3)

The method of claim 3, wherein the subject is administered a 2 μg/ml dose of toremifene.

### Claim 6 (depends on 1)

The method of claim 1, wherein the subject is administered at least 60 milligrams of toremifene.

### Claim 7 (depends on 1)

The method of claim 1, wherein the subject is administered about 60 to about 600 milligrams of toremifene.

### Claim 8 (depends on 1)

The method of claim 1, wherein the subject is administered a dose of fluconazole, wherein the dose ranges from about 2 μg/ml to about 20 μg/ml.

### Claim 9 (depends on 8)

The method of claim 8, wherein the subject is administered a 4 μg/ml dose of fluconazole.

### Claim 10 (depends on 8)

The method of claim 8, wherein the subject is administered a 2 μg/ml dose of fluconazole.

### Claim 11 (depends on 1)

The method of claim 1, wherein the subject is administered at least 100 milligrams of fluconazole.

### Claim 12 (depends on 1)

The method of claim 1, wherein the subject is administered about 100 to about 1000 milligrams of fluconazole.

### Claim 13 (depends on 1)

The method of claim 1, wherein the therapeutically effective combination of toremifene and fluconazole is administered to the subject by a method selected from the group consisting of intravenous administration, intraperitoneal administration, oral administration, topical administration, intra-articular administration, mebulization/inhalation, and subcutaneous administration.

### Claim 14 (depends on 1)

The method of claim 1, wherein the method further comprises administering to the subject a therapeutically effective amount of tamoxifen.

### Claim 15 (depends on 1)

The method of claim 1, wherein the method further comprises administering to the subject a therapeutically effective amount of clomiphene.