# US 9,040,514 B2 · Chlorobis copper (I) complex compositions and methods of manufacture and use

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- Number: US 9,040,514 B2
- Document ID: US9040514B2
- Status: Granted
- Kind: B2
- Application number: 14/237,876
- Filed: 2012-08-09
- Published: 2014-08-28
- Granted: 2015-05-26
- Earliest claimed: 2011-08-09
- Assignees: C Lab Pharma International, S.A.
- Applicants: Sean Kerrigan; Nolan Mente; Charles Louis Albartus Barker
- Inventors: Sean Kerrigan; Nolan Mente; Charles Louis Albartus Barker
- Web page: https://patentgrep.com/patent/US9040514B2

## CPC

- A61K 31/555: containing heavy metals, e.g. hemin, hematin, melarsoprol
- A61K 9/006: {Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays}
- A61K 31/30: Copper compounds
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 31/444: containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61P 25/20: Hypnotics; Sedatives
- A61P 25/24: Antidepressants
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C07F 1/005: {without C-Metal linkages}
- C07F 1/08: Copper compounds
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

A method of manufacturing an anhydrous copper complex of formula C12H10CICuN2O4 and methods of treating neuromuscular and other diseases, including but not limited to fibromyalgia, multiple sclerosis, muscular dystrophy, rheumatoid arthritis, pain, fatigue, sleeplessness, loss of fine motor control, speech loss, inflexibility, Alzheimer's, dementia, amyotrophic lateral sclerosis, depression, lyme disease, lyme disease co-infection, gastroparesis (GP), myopathy, chronic inflammation and/or incontinence. The anhydrous copper complex preferably is administered in a pharmaceutical and/or dietary supplement composition of the invention.

## Claims

### Claim 1

A method of treating lyme disease comprising administering to an animal in need of such treatment a copper complex of formula C12H10ClCuN2O4, wherein the copper complex is anhydrous and has a chemical structure of Formula (I):

### Claim 2 (depends on 1)

The method of claim 1, wherein the animal is a human being and the copper complex is administered sublingually.

### Claim 3 (depends on 2)

The method of claim 2, wherein the compound is administered in a dose between 1 mg and 20 mg per day.

### Claim 4 (depends on 3)

The method claim 3, wherein the compound is administered in a dose between 5 mg and 10 mg per day.

### Claim 5

A method of making an anhydrous copper complex having a chemical structure of Formula (I):
comprising the steps of:
a) adding an effective amount of nicotinic acid, ascorbic acid, and 90% aqueous ethanol to a container;
b) applying heat to said container;
c) stirring the contents of the container;
d) adding cuprous chloride to the container;
e) refluxing and stirring the contents of the container;
f) cooling the contents of the container;
g) filtering out the contents of the container;
h) washing the filtered contents of the container with aqueous ascorbic acid;
i) washing the filtered contents with 90% aqueous ethanol;
j) washing the filtered contents with acetone; and
k) drying the filtered contents;
wherein the method is performed in an atmosphere consisting of an inert gas.