# US 9,040,510 B2 · Interaction control of cationic biocides using labile anionic polyelectrolytes

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- Number: US 9,040,510 B2
- Document ID: US9040510B2
- Status: Granted
- Kind: B2
- Application number: 12/410,513
- Filed: 2009-03-25
- Published: 2009-10-08
- Granted: 2015-05-26
- Earliest claimed: 2008-04-03
- Assignees: Alcon Research, Ltd.
- Applicants: Howard Allen Ketelson; Ryan Desousa; Nissanke L. Dassanayake; Mary E. Luck
- Inventors: Howard Allen Ketelson; Ryan Desousa; Nissanke L. Dassanayake; Mary E. Luck
- Web page: https://patentgrep.com/patent/US9040510B2

## CPC

- A61L 12/143: {Quaternary ammonium compounds}
- A61L 12/14: Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L 12/145: {Polymeric quaternary ammonium compounds}
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Methods of inhibiting the uptake of cationic biocides into medical devices such as contact lenses and implants are described. Methods of stabilizing emulsions containing cationic biocides are also described. In particular, the present invention provides for the use of polymers acting as labile anionic polyelectrolytes to reversibly bind cationic biocides. The reversible binding can reduce the deleterious effects of cationic biocides while maintaining biocidal activity. Preferred polymers include galactomannan and polyvinyl alcohol.

## Claims

### Claim 1

A method of using a galactomannan to inhibit uptake of a cationic biocide into hydrogel biomaterials, the method comprising adding to a composition containing a cationic biocide and a borate a galactomannan in an amount to form a concentration between 0.025 to 0.074% w/v, wherein the composition is adapted for use with hydrogel biomaterials.

### Claim 2 (depends on 1)

A method according to claim 1, wherein the pH of the composition is greater than 7.

### Claim 3 (depends on 1)

A method according to claim 1, wherein the galactomannan is hydroxypropyl guar.

### Claim 4 (depends on 3)

A method according to claim 3, wherein the concentration of hydroxypropyl guar is 0.05%.

### Claim 5 (depends on 1)

A method according to claim 1, wherein the cationic biocide is a polymeric quaternary ammonium compound.

### Claim 6 (depends on 5)

A method according to claim 5, wherein the polymeric quaternary ammonium compound is polyquaternium-1.

### Claim 7

A method of reversibly binding cationic biocides in solution to inhibit uptake of the biocide into hydrogel biomaterials, the method comprising adding hydroxypropyl guar in an amount to form a concentration between 0.025 to 0.074% w/v to a composition containing a cationic biocide and a borate.

### Claim 8 (depends on 7)

A method according to claim 7, wherein the pH of the composition is greater than 7.

### Claim 9 (depends on 8)

A method according to claim 8, wherein the pH of the composition is not greater than 8.

### Claim 10 (depends on 7)

A method according to claim 7, wherein the cationic biocide is a polymeric quaternary ammonium compound.

### Claim 11 (depends on 10)

A method according to claim 10, wherein the polymeric quaternary ammonium compound is polyquaternium-1.

### Claim 12 (depends on 8)

A method according to claim 8, wherein the cationic biocide is a polymeric quaternary ammonium compound.

### Claim 13 (depends on 12)

A method according to claim 12, wherein the polymeric quaternary ammonium compound is polyquaternium-1.

### Claim 14 (depends on 13)

A method according to claim 13, wherein the concentration of hydroxypropyl guar is about 0.05 w/v %.

### Claim 15 (depends on 7)

A method according to claim 7, wherein the concentration of hydroxypropyl guar is about 0.05 w/v %.

### Claim 16 (depends on 1)

A method according to claim 1, wherein the hydrogel biomaterial is a soft contact lens.