# US 9,040,509 B2 · Method of treating human skin and a skin care composition for use in such a method

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- Number: US 9,040,509 B2
- Document ID: US9040509B2
- Status: Granted
- Kind: B2
- Application number: 13/017,858
- Filed: 2011-01-31
- Published: 2011-06-30
- Granted: 2015-05-26
- Earliest claimed: 2002-06-11
- Assignees: Pantarhei Bioscience B.V.
- Applicants: Herman Jan Tijmen Coelingh Bennink; Evert Johannes Bunschoten; Christian Franz Holinka
- Inventors: Herman Jan Tijmen Coelingh Bennink; Evert Johannes Bunschoten; Christian Franz Holinka
- Web page: https://patentgrep.com/patent/US9040509B2

## CPC

- A61K 8/63: Steroids; Derivatives thereof
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/565: not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/10: Anti-acne agents
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/004: {Aftersun preparations}
- A61Q 19/08: Anti-ageing preparations
- A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

One aspect of the invention concerns a cosmetic method of treating human skin by delivering an estrogenic component to said skin. The method comprises applying to the skin a composition containing: (i) at least 5 μg/g of an estrogenic component selected from the group consisting of substances represented by the following formula (I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors; and (ii) a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing. Yet another aspect of the invention relates to a skin care composition comprising the aforementioned estrogenic component and a cosmetically acceptable vehicle.

## Claims

### Claim 1

A cosmetic method of improving wrinkled, lined, dry, flaky, aged, or photodamaged skin comprising applying to the skin a composition comprising:
(i) at least 5 μg of estetrol per g of composition; and
(ii) a cosmetically acceptable vehicle.

### Claim 2 (depends on 1)

The cosmetic method according to claim 1, wherein the composition enhances proliferation of fibroblasts and/or epidermal skin cells.

### Claim 3 (depends on 1)

The cosmetic method according to claim 1, wherein the composition improves skin thickness and/or skin elasticity.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the composition contains at least 10 μg/g of estetrol.

### Claim 5 (depends on 1)

The cosmetic method according to claim 1, wherein the composition is applied to facial skin or neck skin.

### Claim 6 (depends on 1)

The cosmetic method according to claim 1, wherein the composition is applied at least once a day during a period of at least 3 days.

### Claim 7 (depends on 1)

The cosmetic method according to claim 1, wherein virtually all of the composition that has been applied to the skin penetrates the skin.

### Claim 8

A method of promoting wound healing comprising applying to a wounded tissue or to tissue in a vicinity of a wound a composition comprising:
(i) at least 5 μg of estetrol per g of composition; and
(ii) a cosmetically acceptable vehicle.

### Claim 9

A method of treating or preventing acne comprising applying to skin that is affected by acne or that is at risk of being affected by acne a composition comprising:
at least 5 μg of estetrol per g of composition; and
(ii) a cosmetically acceptable vehicle.

### Claim 10

A pharmaceutical or cosmetic composition for topical administration comprising:
at least 5 μg of estetrol per g of composition; and
(ii) a cosmetically acceptable vehicle.

### Claim 11 (depends on 1)

The cosmetic method according to claim 1, wherein the composition is a lotion, salve or a cream.